QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 286 matching student topics
Displaying 25–36 of 286 results
Engineering the prostate tumour microenvironment in organ-on-a-chip systems
Prostate cancer remains one of the leading causes of global death. The tumour microenvironment (TME) including blood vessels, immune cells, fibroblasts, and the extracellular matrix (ECM) possesses disease-specific biophysical and biological factors that are difficult to recapitulate using conventional in vitro cell culture models.The absence of these factors, however, causes cells to display abnormal morphologies, polarisation, proliferation, and drug responses, thereby limiting the ability to translate research findings from traditional cell culture into clinical practice.Recent advances in organ-on-a-chip technology enable …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Designing interactive art experiences that engage people with the issues around aged care
BackgroundThis PhD, concerned with the creation of interactive art works and funded through an ARC/QUT scholarship, is part of a larger ongoing project: ARC Discovery DP210100589 "Amplifying the Impact of the Royal Commission into Aged Care" (CI's Miller, Holland-Blatt, Thompson Seevinck, Gott.)About the Discovery project (the PhD study context)"The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Creative Industries, Education and Social Justice
- School
- School of Design
- Research centre(s)
-
Design Lab
Understanding the external surface of fungal mycelia
The way in which fungal cultures grow in liquid cultures are can have a major impact on scale up and producing material. Here, we will examine the growth of three fast-growing filamentous fungi and try understand how various growth parameters affect the morphology that will range from loose mycelia to compact pellets.Fungal morphology is affected by inoculum (form, concentration and growth stage), media components (type and concentration of carbon, nitrogen and phosphate, trace minerals, pH, salt content), dissolved gases (dissolved …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Biology and Environmental Science
- Research centre(s)
- Centre for Agriculture and the Bioeconomy
Modelling and managing uncertain Antarctic species networks
Antarctic ecosystems are complex, and data is limited since it is expensive to collect. Species including penguins, seabirds, invertebrates, mosses, and marine species interact in food webs which can be modelled as mathematical networks. These networks can be large, span across terrestrial and marine systems, and are changing in response to environmental changes.These ecological networks can be modelled using differential equation predator prey models like Lotka-Volterra to describe these interactions. However, the relationships between species are not always known, or …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
Centre for the Environment
Optimal conservation management in uncertain Antarctic environments
Species and ecosystems in Antarctica are threatened. Optimal biodiversity conservation is an interdisciplinary field combining mathematical modelling and optimisation with ecology and conservation. We can use mathematics to understand the system, model how management actions might impact it, and then optimise which actions should be used. For example, we can explore where protected areas should be placed, how species should be managed, or how tourist impacts should be reduced. However, the complexities of conservation in Antarctica necessitate the application of …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
Centre for the Environment
Community and Public Health Nutrition Workforce
The training of a specialised community and public health nutrition (CPHN) workforce assumes they are optimally placed to address food and nutrition issues at a population and community level. However, concomitant with the rise of diet as the leading risk factor contributing to the burden of disease in Australia, has been a dramatic disinvestment in this workforcePermanent, full time nutritionist positions embedded in communities or population settings are few. If an organisation invests in a nutrition intervention it is increasingly …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Exercise and Nutrition Sciences
Renewal and differentiation in human neural stem cells and their application to understanding neurological disorders
The effective regeneration of brain tissue requires an understanding of the factors mediating the damage as well as the integration of new/replacement cells to form new functional neural networks. The isolation and expansion of human stem cells and limited neural lineage differentiation have provided the foundation for strategies in the treatment of neurodegenerative disorders. We utilise iPSC-derived NPCs and patient-derived (Alzheimer’s disease; AD) iPSCs and neural lineage differentiation of hMSCs, iPSC NPCs and AD iPSCs in neuronal and glial culture …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer
Prostate cancer is an androgen dependent cancer and treatments are aimed at preventing activation of the androgen receptor. Part of the development of resistance to therapies involves prostate cancers reprogramming their metabolism to overcome metabolic stress induced by these therapies and support growth and survival. This reprogramming involves increases in the rate of glycolysis and intermediate pathways branching from glycolysis. Previously in our laboratory, the natural compound, beta-carboline dimer, BD, was identified to have potent effects on cell viability, cell …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Improving cow fertility: targeting exosome-responsive pathways
Exosomes are small (40-120 nm), stable, lipid bilayer nanovesicles identified in biological fluids (e.g. in Until recently, genetic selection in dairy cows has focused primarily on milk production traits, with very few countries including functional traits such as fertility in selection indices. Poor reproductive efficiency in dairy herds results in fewer calves, reduced milk production, high involuntary culling rates and increased cow maintenance costs. The need for, and utility of, markers of early onset of diseases (or vulnerability to diseases) …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Early detection of complications in human pregnancy
Complications of pregnancy, including preterm birth represent the major causes of fetal and neonatal morbidity and mortality and potentially affect childhood and adult susceptibility to both cardiac and metabolic diseases. Early detection of these disorders is, therefore, essential to improve health outcomes for mother and baby.Exosomes are small (40-120 nm), stable, lipid bilayer nanovesicles identified in biological fluids (e.g. in milk, blood, urine and saliva). They contain a diverse array of signalling molecules, including mRNA, microRNA (miR), proteins, lipids and …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Participatory Visualisation of Smart City Data
This PhD project will be affiliated with FrontierSI and Value Australia and contribute to its goals and objectives around smart cities, digital twins, and automated land valuations. Although consumers contribute much of the data upon which these smart city technologies operate, its systems often remain opaque black boxes closed off to public understanding, scrutiny and control. There are also serious concerns around privacy and loss of autonomy.This PhD project addresses these issues by exploring new methods for the participatory visualisation …
- Study level
- PhD
- Faculty
- Faculty of Creative Industries, Education and Social Justice
- School
- School of Design
- Research centre(s)
-
Design Lab
Investigating differences in downstream signalling mediated by two isoforms of FGFR2 in endometrial cancer
FGFR2 encodes two alternatively spliced isoforms that differ in their ligand binding domain and the combination of tissue specific expression of these isoforms and tissue specific expression of the FGF ligands is the foundation of normal paracrine signalling. Isoform switching from FGFR2b (inclusion of exon 8) to FGFR2c (inclusion of exon 9) occurs in tumorigenesis as it establishes an autocrine loop in epithelial cancer cells.We have previously published a detailed investigation into differences between wildtype FGFR2b and mutant FGFR2b following …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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