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Therapeutic opportunities targeting epigenetic-metabolism crosswalks in cancer

Epigenetic and metabolic pathways in cancer cells are highly interconnected. Epigenetic landscape in cancer cells is modified by oncogene-driven metabolic changes. Metabolites modulate the activities of epigenetic modifying enzymes to regulate the expression of specific genes. Conversely, epigenetic deregulation that occurs in cancer affect the expression of metabolic genes, thereby altering the metabolome. These changes all coordinately enhance cancer cell proliferation, metastasis and therapy resistance. The overall aim of the project is to understand the link between the activity of …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Computational drug repurposing for neuropsychiatric disease

While hundreds of robust genetic associations have been found for neuropsychiatric disease (such as schizophrenia, major depression, and anxiety) understanding the exact molecular mechanisms leading to disease onset and progression remains challenging. Inherited (i.e. genetic) risk factors for many neuropsychiatric diseases converge on genes that are co-ordinately expressed (co-expressed) in a disease-relevant tissue (e.g. brain). The study of how genetic risk factors affect co-expressed genes (i.e. gene co-expression analysis) has the potential to uncover new biological processes underlying disease onset. …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Investigation of genetic factors that contribute to concussion and its outcomes

The health outcomes from traumatic brain injuries (TBIs) and concussion depend on the nature of the injury, but response also varies greatly between individuals, suggesting that genetic factors may play a role. In particular, due to effects of head trauma on balances of ions, neurotransmitters and energy use in the brain, there is suggestion that variation in the genes that encode proteins involved in these pathways, e.g. ion channels, may affect the risk of, as well as response to a …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM03)

Project code:BIOM03Project aims and objectives:Liver disease is a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism is associated with many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease.These two inter-related research themes are the focus of research in the Hepatogenomics Research Group in the School of Biomedical Sciences and IHBI; we hope to advance our understanding of these disorders at a molecular level with the …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Infection kinetic changes that occur within macrophage-adapted Chlamydia

Chlamydia trachomatis is an obligate intracellular, bacterial pathogen. C. trachomatis infections of the human reproductive tract affect approximately 127 million people globally each year. The major concern of C. trachomatis infections is their ability to cause infertility in both men and women, by damaging the upper reproductive tracts. However, we are still lacking information about how Chlamydia travels around the reproductive tract, and reaches the upper tract (ovaries and testes in particular) to cause this damage.Recent research has shown that …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

The effect of genetic predisposition to traits on recruitment bias

Project code:QIMR01Area of Research:CancerProject aims and objectives:Population based research projects only recruit those willing to take part in a study, therefore potentially introducing a recruitment bias. As part of the PISA study (Prospective Imaging Study of Aging: Genes, Brain, and Behaviour) we are leveraging our extensive in-house cohorts drawn from genetic studies of approximately 16,000 individuals. All participants have been invited to complete an online survey on cognition and behaviour, lifestyle and family history. The fact that we already have …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Understanding fundamental differences in novel Yarrowia lipolytica strains and their ability to utilise lipid-rich wastewaters

Yarrowia lipolytica is a yeast that is capable of using a host of lipids as a carbon source. The yeast is used for equine and pet food supplements and holds great promise a probiotic and nutritional supplement.We have six unique Australian strains that need to be characterised and compared using various omics platforms. Additionally, growth in various lipid-rich aqueous wastewaters will be compared. Wild type strains will also be genetically altered to develop strains with improved growth and substrate utilisation …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Biology and Environmental Science
Research centre(s)

Understanding the molecular mechanisms of microbial adaptation to growth on biorefinery feedstocks

Biorefineries are centralised industrial facilities that transform waste and by-products from the crop and animal production sectors into products such as food, energy, and materials. As such, they are central 'pillars' of the circular bioeconomy.Some biorefinery feedstocks are challenging to transform using microorganisms because they contain 'unusual' carbohydrates or a complex mixture of inhibitory compounds.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Biology and Environmental Science
Research centre(s)

The interplay between environmental and genetic risk factors in the etiology of mental health disorders

Mental health disorders (e.g., depression, anxiety, substance use) are the leading cause of global disease burden in the young adult population. Twin and family studies show that both genetic and environmental factors play a large role in the aetiology of these disorders. The Translational Neurogenomics group http://www.qimrberghofer.edu.au/lab/translational-neurogenomics/ aims to identify genetic risk factors for a range of mental health and substance use disorders, and investigate the interplay between genetic and environmental risk factors.UK Biobank is a major national and international …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

Epigenetic regulation of non-coding RNAs in hypoxic tumours

In solid tumours, hypoxia occurs as a result of limitation on oxygen diffusion in avascular primary tumours or their metastases. Persistent hypoxia, significantly reduces the efficacy of radiation and chemotherapy and lead to poor outcomes. This is mainly due to increase in pro-survival genes that suppress apoptosis, enhance tumour angiogenesis, the epithelial-to-mesenchymal transition, invasiveness and metastasis. Much of tumour hypoxia research has been centred on examining the transcriptional targets of hypoxia inducible factors (HIFs).HypothesisEpigenetic changes mediate the effect of hypoxia …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Should Australia legislate to allow three parent babies?

In 2015, the United Kingdom legalised a form of in vitro fertilisation (IVF) therapy known as ‘three-parent IVF’ and, less colloquially, mitochondrial replacement therapy (MRT). This IVF procedure is aimed at enabling women who have mitochondrial diseases that would normally be passed down to their offspring to have a healthy child instead. The technique involves removing faulty mitochondria from the intended mother’s egg and replacing them with mitochondria from a generically unrelated woman (by transferring the intended mother's nucleus to …

Study level
PhD
Faculty
null
School
null
Research centre(s)
null
null

Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer

Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

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