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Developing composite products for use in light steel wall and floor systems

The project will investigate the potential use of a range of composite products made of gypsum plasterboard, steel sheeting and insulation foams to improve the fire resistance of light steel wall and floor systems. It will involve investigating the potential composite products’ suitability, conducting fire tests of small scale wall/floor assemblies (1.2mx.1.2m) made of such composite products to understand how they behave in fire and determine their fire resistance levels. Civil and Mechanical Engineering students with interest in structural and …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Civil and Environmental Engineering

Investigating genetic variants involved in Wilson disease and copper metabolism using genome editing

Wilson disease (WD) is a genetic disorder of copper metabolism. It can present with hepatic and neurological symptoms, due to copper accumulation in the liver and brain (1). WD is caused by compound heterozygosity or homozygosity for mutations in the copper transporting P-type ATPase gene ATP7B. Over 700 ATP7B genetic variants have been associated with WD. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. Early diagnosis and treatment are important for successful management of the disease. …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

Targeting the ferroxidase hephaestin to treat iron loading disorders

Iron overload diseases represent one of the largest groups of inherited disorders worldwide. The primary iron overload disorder HFE-related haemochromatosis is the most common autosomal recessive disease in humans, affecting 1 in 180 Australians and leading to liver cancer, dementia, diabetes and arthritis if untreated. Iron loading anaemias such as beta-thalassaemia have equally devastating effects and are prominent in southern European, Middle Eastern and southeast Asian populations.These two forms of iron loading share the common features of increased dietary iron …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Investigating metal metabolism using cell and molecular biology techniques

Metals such as iron and copper are essential for life. Low or high amounts in the body can be damaging and hence levels are tightly regulated through various molecular pathways. Defects in these pathways can lead to genetic disorders such as haemochromatosis (iron overload), Wilson's disease (copper overload) or anaemia (iron deficiency).Increased understanding of the pathways regulating iron or copper homeostasis will be useful for the development of diagnostics and therapeutics for treating these disorders. This project will use cell …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

Identification and functional characterisation of genetic modifiers of iron overload

Iron is an element essential for virtually all life forms; aberrant iron metabolism is linked to many diseases. These include cancers, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, iron overload and iron deficiency disorders, iron-loading anaemias, and the anaemia associated with chronic disease. Central to proper iron regulation is the appropriate expression and activity of the liver-expressed regulatory peptide, hepcidin, and the iron exporter, ferroportin (FPN). Modulating the expression and activity of hepcidin and FPN, and their interaction is …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Bushfire performance of lightweight and fire resistant wall panels

This project will investigate the structural bushfire performance of lightweight and fire resistant cement based blocks and wall panels. This includes axial compression tests and fire resistance tests of individual blocks currently available in the industry. The performance will be summarized based on the raw materials and the mix proportion of the blocks.

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Civil and Environmental Engineering
Research centre(s)
Centre for Materials Science

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