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Prostate cancer transcriptomics (Honours and Master of Philosophy)

At the Australian Prostate Cancer Research Centre QLD, we are interested in the cellular adaptive response processes leading to therapy resistance in advanced prostate cancer.A focus area of our research is studying the transcriptome changes in prostate cancer cell lines, xenograft models and patient samples using RNA sequencing technologies.By integrating our large in-house repository of RNAseq data sets with publicly available studies, this project will further explore the cellular heterogeneity of prostate tumours and the plasticity of cancer cells in …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Optimising outcomes for children and adolescents diagnosed with cancer

Each year in Australia, around 1200 children and adolescents are diagnosed with cancer and while most (84%) will achieve 5-year disease free survival, all will suffer significant distress from symptoms associated with cancer and treatment.High symptom burdens can lead to numerous negative outcomes that persist for many years beyond cancer treatment. These include disruptions normal development, schooling, relationships, careers, and living an independent life. This is concerning, because young people have a long time to live with these negative consequences, …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Nursing
Research centre(s)
Centre for Healthcare Transformation
Cancer and Palliative Care Outcomes Centre

Biological and clinical impact of the association of germline variations in KLK3 (PSA) gene in prostate cancer

Prostate cancer is the most frequently occurring cancer (after skin cancers) in Australian males, and the second most common cause of cancer death. While the 5-year survival rate for localised disease approaches 100%, extra-prostatic invasion results in a poorer prognosis. Kallikreins are serine proteases, which are part of an enzymatic cascade pathway activated in prostate cancer (Lawrence et al 2010). The most well-known member is prostate specific antigen (PSA) or the KLK3 protein, encoded by the Kallikrein 3 (KLK3) gene, …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Two dimensional heterostructures on SiC for new electronics

The present electronic technology is approaching the limit to the smallest circuit element achievable, and the future electronic devices will depend critically on the development of novel approaches. Two dimensional materials seem to offer an exciting perspective, and the advent of graphene (a single layer of carbon atoms in a honeycomb structure) sparked a huge interest, but its application to electronics are limited by the absence of a band gap.A new perspective has been open by other 2D materials which …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Advanced artificial intelligence based ultrasound imaging applications

Our research in the space of advanced quantitative medical imaging is investigating how to use ultrasound as a real time volumetric mapping tool of human tissues, to guide in a reliable and accurate way complex medical procedures1. We have developed several novel methods which make use of the most cutting-edge artificial intelligence technology2. For example, to show where the treatment target and the organs at risk are at all times during treatments in radiation therapy3, 4; or to inform robots …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Clinical Sciences
Research centre(s)
Centre for Biomedical Technologies

Corporate social and environmental performance information and related accountability practices

Due to stakeholder attention, companies are increasingly disclosing social and environmental performance information within their annual and corporate social responsibility (CSR) reports. OutcomesThis study will investigate whether these disclosures reflect real performance, and thereby create accountability practices by corporations. Both Australian and international companies are the focus of this project.The project considers both qualitative and quantitative methods.

Study level
Master of Philosophy
Faculty
null
School
null
Research centre(s)
null
null

Leading diversity

Diversity is a buzz word in many organizations today. While having a diverse team promise potential for innovation and creativity, it can also create many challenges. Leading diversity will be an important capability for future leaders.

Study level
PhD
Faculty
Faculty of Business and Law
School
School of Management
Research centre(s)
Centre for Future Enterprise
Australian Centre for Entrepreneurship Research

Detecting negative interactions in online setting

The purpose of this research is to provide a methodology to detect and mitigate destructive patterns that are generated in crowdsourcing systems and result in a negative consequence through contributors’ interactions.Vote manipulation is a form of co-destruction that can result from intentionally biasing a rating. In Wikipedia, co-destruction can happen for example as a result of blanking pages or inserting unrelated content to the page by a group of people.Our ultimate goal is to provide guidance when setting up crowdsourcing …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Information Systems

Aggressive lane change and cornering detection in the connected vehicle environment

BackgroundSoon, vehicles equipped with Cooperative Vehicle Intelligent Transport Systems (C-ITS) will be on Australian roads. C-ITS will enable several safety functions (use cases) which are expected to improve road safety. After-market products C-ITS based has the advantage of being a feasible solution for existing vehicles with outdated technologies, which might be the origin of the road safety problems. Moreover, C-ITS data enables real-time evaluation of driver behaviour which can be used in several applications such as driver assistance and early …

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Computer Science

Decision modelling in blockchain adoption and environmental implications

Due to the decentralised and immutable nature of distributed ledger systems, blockchain has become a critical priority for organisations across the world. The global blockchain market is expected to grow from $1.57 billion in 2018 to $162.84 billion by 2027.From an ecological perspective, blockchain has raised environmental concerns due to increasing computational power that is required to operate energy-intensive consensus mechanisms. However, it also has the potential to help promote renewable energy through a variety of blockchain-based use cases such …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Information Systems

Decision modelling to overcome intergenerational discounting

This project aims to address a key obstacle to climate action: intergenerational discounting, a phenomenon that explains the tendency for people to prefer smaller benefits for themselves now, rather than larger benefits for future generations. Intergenerational discounting becomes even more problematic due to a growing global population and increasingly intensive use of natural resources.In this project, we follow the design science approach and aim to establish design principles necessary for decision modelling to overcome intergenerational discounting and achieve genuine and …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Information Systems

Electrothermal film heaters

Flexible electrothermal heaters have attracted a growing interest because of their broad applications in wearable electronics, including warming garments, and as flexural warmers for medical devices and vehicles. Traditional electrothermal materials such as ferro chromium (FeCr)-based alloys have disadvantages such as heavy weight, rigidity and low heating efficiency. Indium tin oxide (ITO) is widely used in commercial products due to its high transparency and high electrical conductivity. However, the finite reserve of indium has resulted in an increasing price of …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Chemistry and Physics

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