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Developing a precision oncology workflow for Osteosarcoma treatment

Osteosarcoma (OS) is the most common malignant bone tumour that primarily affects children and adolescents. With approximately 400 diagnosed cases/year in Australia, OS has the lowest survival rate of all solid cancers and is the leading cause of cancer-related death in Queensland adolescents. Unfortunately, 3 in 4 patients will not survive longer than five years following diagnosis with metastatic OS. Clinical “one size fits all” treatment strategies results in highly variable and unacceptably poor patient responses. Shockingly, both the OS …

Study level
PhD, Master of Philosophy
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology

Osteosarcoma (OS) is the most common malignant bone tumour affecting children and adolescents. Importantly, clinical outcomes have not improved for decades, and bone tumours remain to be a leading cause of cancer-related death in adolescents.By identifying ideal treatment approaches for each individual patient, precision oncology has the potential to significantly improve these outcomes. Yet, its widespread application is hindered by a lack of biomaterials that support the reproducible and robust generation of patient-derived osteosarcoma organoids in vitro.Therefore, this project will …

Study level
PhD, Master of Philosophy
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

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