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Illuminating the microbial world using genome-based fluorescence microscopy

Our understanding of microbial diversity on earth has been fundamentally changed by metagenomic characterisation of natural ecosystems. Traditional approaches for visualising microbial communities are time-consuming and provide limited information about the identity of specific microorganisms.The proposed research aims to combine single cell genomics and super resolution microscopy for novel, high-throughput, genome-based techniques to visualise microorganisms, plasmids and viruses, with strain level specificity.The application of these highly scalable approaches will provide comprehensive and unprecedented insight into the fine-scale dynamics and evolution …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Spatial localisation of immunoglobulin A in the gastrointestinal tract.

Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment approaches to improve transplant outcome for …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Advanced electron microscopy for sustainable nanocatalysis

The systematic and detailed characterisation of heterogeneous catalysts is critical for design of effective and stable catalytic materials, since it allows one to understand the correlation between their structure and physicochemical properties.Especially, it is important to monitor the structural evolution of catalytic materials and their active sites in a controllable environment and under realistic reaction conditions.Thus, we propose to use a powerful combination of aberration-corrected high-resolution TEM and in situ TEM experiments which allow us to gain extensive knowledge about …

Study level
PhD
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Two dimensional heterostructures on SiC for new electronics

The present electronic technology is approaching the limit to the smallest circuit element achievable, and the future electronic devices will depend critically on the development of novel approaches. Two dimensional materials seem to offer an exciting perspective, and the advent of graphene (a single layer of carbon atoms in a honeycomb structure) sparked a huge interest, but its application to electronics are limited by the absence of a band gap.A new perspective has been open by other 2D materials which …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Application of fluorescence-activated cell sorting and confocal microscopy for the study of the microbial communities responsible for nutrient removal from domestic wastewater

The removal of nutrients like carbon, nitrogen and phosphorus from wastewater is critical to the prevention of eutrophication in receiving water systems and is carried out by complex microbial communities.Eutrophication can have devastating consequences on aquatic life and natural ecosystems, with toxic algal blooms also posing a risk to human health.Understanding the microbiology of phosphorus (P) removal from wastewater is considered essential to knowledge-based optimisation of enhanced biological P removal (EBPR) systems.Most of the species in these systems are novel …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

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