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Found 28 matching student topics

Displaying 25–28 of 28 results

A mathematical model of disrupting cell-to-cell communication by bacteria

The emergence of resistance of bacteria to antibiotics presents a global healthcare challenge that intensifies the search for strategies to increase the effcacy of therapy. Several mechanisms are involved in resistance of bacteria against antibiotics such as mutations in genes, horizontal gene transfer, and biofilm formation. Bacteria can communicate with each other through production and response to local concentration of small molecules called autoinducers.This mechanism is called quorum sensing (QS).It has been suggested that QS can influence the resistance of …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Dissecting the molecular and cellular basis of melanoma susceptibility

Several factors strongly influence an individual’s chance of developing melanoma. Paramount amongst these are the number of moles (nevi) present on the skin, cumulative levels of UV exposure and skin pigmentation phenotype. Numerous Genome Wide Association Studies (GWAS) we have identified gene variants at a number of loci that are strongly associated with cutaneous nevi (mole) counts, UV damage response and accordingly susceptibility of individuals to develop melanoma. Currently the functional impact of genetic variants in the genes IRF4, PLA2G6 …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Monitoring Corneal Immune Cell Changes After Anti-Inflammatory and Immunosuppressant Eye Drops Using In Vivo Confocal Microscopy

This project investigates how corneal immune cells in the human eye respond to topical anti-inflammatory and immunosuppressant eye drops. By using in vivo confocal microscopy, we aim to monitor real-time cellular changes to better understand treatment effects in common ocular surface conditions.

Study level
Honours
Faculty
Faculty of Health
School
School of Clinical Sciences
Research centre(s)
Centre for Vision and Eye Research
Centre for Vision and Eye Research

Characterising drivers of melanoma cell heterogeneity

Tumour cell heterogeneity is linked to tumour progression through the generation of divergent cellular behaviours such as proliferation, survival, invasion and therapy resistance. Crucially, conventional and targeted therapies generally only target highly proliferative cells in tumours leading to initial tumour regression, however alternative sub-populations underpin the return of treatment refractory disease and facilitate metastatic spread. Our laboratory is focused on understanding the regulatory drivers of cellular plasticity in melanoma to better understand progression and metastatic spread of this disease and …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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