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Life cycle assessments in the hospital space for waste reduction

Recovering, recycling, reuse and reducing waste in the health sector becomes more and more important as it will help hospitals to become more sustainable and to reduce their impact on greenhouse gas emissions. Life cycle assessments of materials, for examples plastic packaging, is an important tool to establish the best practice for recovery and recycling of these materials.

Study level
Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)

Centre for a Waste-Free World

Renewal and differentiation in human neural stem cells and their application to understanding neurological disorders

The effective regeneration of brain tissue requires an understanding of the factors mediating the damage as well as the integration of new/replacement cells to form new functional neural networks. The isolation and expansion of human stem cells and limited neural lineage differentiation have provided the foundation for strategies in the treatment of neurodegenerative disorders. We utilise iPSC-derived NPCs and patient-derived (Alzheimer’s disease; AD) iPSCs and neural lineage differentiation of hMSCs, iPSC NPCs and AD iPSCs in neuronal and glial culture …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Characterisation of a novel protein co-amplified with the n-MYC oncogene

The MYCN oncogene is amplified in a number of tumour types, including Neuroblastoma (NB) and Neuroendocrine Prostate Cancer (NEPC), where it is associated with worse patient prognosis, as compared to non-amplified tumours. However, the high expression of MYCN (encoding the n-MYC protein) alone in non-amplified tumours is associated with better patient prognosis and less aggressive disease. This suggests that other genes co-expressed in MYCN amplified tumours may be responsible for mediating the aggressive traits of n-MYC. Our team has identified …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

A novel molecular targeted therapy for anaplastic prostate cancer

In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Eribulin effects on epithelial mesenchymal plasticity and therapy response

This proposal builds on data showing reversal of TGFbeta- or 5FU-induced epithelial mesenchymal transition (EMT) in breast cancer cell lines in vitro and in vivo by eribulin (1, 2). Given the established relationship between EMT and therapy resistance in a wide range of scenarios (3-5), this potential of eribulin to reverse EMT and sensitise breast cancer cells to therapy has wide-reaching implications for improved patient outcomes. Evidence for this potential at the therapeutic level has been seen with in vitro …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Characterising drivers of melanoma cell heterogeneity

Tumour cell heterogeneity is linked to tumour progression through the generation of divergent cellular behaviours such as proliferation, survival, invasion and therapy resistance. Crucially, conventional and targeted therapies generally only target highly proliferative cells in tumours leading to initial tumour regression, however alternative sub-populations underpin the return of treatment refractory disease and facilitate metastatic spread. Our laboratory is focused on understanding the regulatory drivers of cellular plasticity in melanoma to better understand progression and metastatic spread of this disease and …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Macromolecular barcoding for tracing plastic materials for the circular economy: a game changer for recycling

The reduction and management of plastic waste is perhaps the most critical challenge facing modern economies and plastic pollution cannot be resolved by generic approaches to research or to problem-solving. The Soft Matter Materials Team aims to resolve the anonymity and ubiquity of plastics by pioneering a simple optical readout system that can identify the uniquely coded information in macromolecules that have been embedded in plastics.In this project, optically readable macromolecular barcodes based on a system of excimer fluorescence switch-on …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

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