QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 258 matching student topics
Displaying 1–12 of 258 results
Using systems architecture to model neuropathic pain
Neuropathic pain effects '1 in every 10 adults over the age of 30'. The treatments available for neuropathic pain can at best be described as having 'moderate efficacy'. Due to the nature of neuropathic pain, the ability to scientifically study and understand its fundamental causes has been limited to animal models and trials. There are over 27 animal models for neuropathic pain where pain has been induced by macroscopic and microscopic nerve lesions, chemotherapy, viral infections and diabetes mellitus.Looking at …
- Study level
- PhD
- School
- School of Mechanical, Medical and Process Engineering
Predicting good sleep using computer science: Can we use machine learning to find out 'what's the best bed?'
In the Westernised world a person typically spends one third of their life in bed, with more time spent sleeping in a bed than in any other single activity. Sleep amount and quality of sleep have a direct impact on mood, behaviour, motor skills and overall quality of life. Yet, despite how important restful sleep is for the body to maintain good health, there is a comparatively small amount of studies evaluating key multi-factorial determinants of restful sleep in non-pathological, …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Engineering response to climate emergency with zero carbon footprint for building construction by 2030 using circular economy principles
We as engineers can make a contribution to address the current climate emergency.The Australian Sustainable Built Environment Council report (2016) found that if Australia's built environment sector reaches zero carbon emissions for the operation of residential and commercial buildings by 2050, it could contribute 28% to the country's 2030 emissions reduction target and save up to AU$20 billion.In this project we will consider the application of the circular economy, which is based on the principles of designing out waste and …
- Study level
- PhD, Honours
- Faculty
- Faculty of Engineering
- School
- School of Civil and Environmental Engineering
- Research centre(s)
- Centre for Materials Science
Centre for a Waste-Free World
Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology
Osteosarcoma (OS) is the most common malignant bone tumour affecting children and adolescents. Importantly, clinical outcomes have not improved for decades, and bone tumours remain to be a leading cause of cancer-related death in adolescents.By identifying ideal treatment approaches for each individual patient, precision oncology has the potential to significantly improve these outcomes. Yet, its widespread application is hindered by a lack of biomaterials that support the reproducible and robust generation of patient-derived osteosarcoma organoids in vitro.Therefore, this project will …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Engineering the prostate tumour microenvironment in organ-on-a-chip systems
Prostate cancer remains one of the leading causes of global death. The tumour microenvironment (TME) including blood vessels, immune cells, fibroblasts, and the extracellular matrix (ECM) possesses disease-specific biophysical and biological factors that are difficult to recapitulate using conventional in vitro cell culture models.The absence of these factors, however, causes cells to display abnormal morphologies, polarisation, proliferation, and drug responses, thereby limiting the ability to translate research findings from traditional cell culture into clinical practice.Recent advances in organ-on-a-chip technology enable …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Developing a precision oncology workflow for Osteosarcoma treatment
Osteosarcoma (OS) is the most common malignant bone tumour that primarily affects children and adolescents. With approximately 400 diagnosed cases/year in Australia, OS has the lowest survival rate of all solid cancers and is the leading cause of cancer-related death in Queensland adolescents. Unfortunately, 3 in 4 patients will not survive longer than five years following diagnosis with metastatic OS. Clinical “one size fits all” treatment strategies results in highly variable and unacceptably poor patient responses. Shockingly, both the OS …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Modelling of electrochemical CO2 capture and conversion
Renewable electricity is remarkably cheap, and is only going to get cheaper. However, existing state-of-the-art CO2 capture and conversion processes use thermal energy (typically generated by burning natural gas). This modelling project will investigate electrochemical techniques for capturing CO2 from air (direct air capture) and converting it to useful chemicals and materials.
- Study level
- PhD
- School
- School of Mechanical, Medical and Process Engineering
Develop microfluidic technologies for cardiovascular and cerebrovascular diseases
The sudden rupture of vulnerable atherosclerotic plaques and subsequent thrombosis formations are responsible for most acute vascular syndromes, such as myocardial infarction and stroke. Many victims who are apparently healthy die suddenly with no prior symptoms. Such deaths could be prevented through surgery or alternative medical therapy, if vulnerable plaques were identified earlier in their natural progression.To address this pressing need, we're developing simple-to-use, high-throughput and highly-informative microfluidic biochips to understand the sequences of molecular events underlying biomechanical thrombosis (mechanobiology). …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Development of bioengineered 3D tumour models for preclinical breast cancer research
3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate 'mini-tumours-in-a-dish' from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
A soft robotic manipulator for spinal surgery
The geriatric population in Australia (4.2 million 2020, ABS), is growing steadily with numbers expected to double in the coming years. Incidences of spinal disorders requiring surgical treatment are therefore predicted to increase, incurring an estimated lifetime cost of AUD 3.7 billion per case (The Treasury). Robotics, an increasingly important component of modern medicine, is well suited to address the minimally invasive surgical needs of treating the spine.This project proposes the use of a soft-robotic manipulator to carry out spinal …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Electrical Engineering and Robotics
- Research centre(s)
- Centre for Robotics
How do healthy people sleep? Biomechanics, physiology, and environment - what matters most?
In the Westernized world a person typically spends one third of their life in bed, with more time spent sleeping in a bed than in any other single activity. Sleep amount and quality of sleep have a direct impact on mood, behaviour, motor skills and overall quality of life. Yet, despite how important restful sleep is for the body to maintain good health, there is a comparatively small amount of studies evaluating key multi-factorial and biomechanical determinants of restful sleep …
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
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