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Found 15 matching student topics

Displaying 13–15 of 15 results

Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer

Prostate cancer is an androgen dependent cancer and treatments are aimed at preventing activation of the androgen receptor. Part of the development of resistance to therapies involves prostate cancers reprogramming their metabolism to overcome metabolic stress induced by these therapies and support growth and survival. This reprogramming involves increases in the rate of glycolysis and intermediate pathways branching from glycolysis. Previously in our laboratory, the natural compound, beta-carboline dimer, BD, was identified to have potent effects on cell viability, cell …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Re-localisation in natural environments

Re-localisation in robotics involves the process of determining a robot's current pose, consisting of its position and orientation. This can either be within a previously mapped and known environment (i.e. prior map) or relative to another robot in a multi-agent setup. Re-localisation is essential for enabling robots to perform tasks such as autonomous monitoring and exploration seamlessly, even when they encounter temporary challenges in precisely tracking their location in GPS-degraded environments. For instance, consider the 'wake-up' problem, where a robot …

Study level
PhD
School
School of Electrical Engineering and Robotics

Emergence of curvature-dependent growth in mathematical models of tissue invasion

The growth of biological tissues in 3D-printed scaffold pores occurs under strong geometric controls depending on the shape and size of the pores. How this control emerges from the interaction between spatial constraints and biological processes such as cell migration and cell proliferation remains largely unknown. Existing phenomenological models of tissue growth hypothesise growth laws which directly involve curvature without considering cellular mechanisms.Recently, a reaction–diffusion mathematical model of tissue growth in porous scaffolds was proposed to investigate cell-level behaviour using …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Biomedical Technologies

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