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Found 14 matching student topics

Displaying 1–12 of 14 results

Strain-level characterisation and visualisation of microbial communities associated with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low resolution. Furthermore, these studies have predominantly focused on bacterial populations, …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Identifying emergent ecosystem responses through genes-to-ecosystems integration at Stordalen Mire

Permafrost thaw induced by climate change is predicted to make up to 174 Pg of near-surface carbon (less than 3m below the surface) available for microbial degradation by 2100. Despite having major implications for human health, prediction of the magnitude of carbon loss as carbon dioxide (CO2) or methane (CH4) is hampered by our limited knowledge of microbial metabolism of organic matter in these environments. Genome-centric meta-omic analysis of microbial communities provides the necessary information to examine how specific lineages …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Spatial localization of immunoglobulin A in the gastrointestinal tract

Project code:QIMR05Area of Research:CancerProject aims and objectives:Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Multi-microbial 3D printing for screening microbiome functions

The ability to 3D print bacteria has relevance to a wide range of applications, ranging from developing novel anti-microbial modalities to probiotics for promoting human health.Traditional culture techniques used in microbiology such as agar plates and suspension cultures have limited spatio-temporal control over the bacteria microenvironment as well as their interaction partners - in particular, mammalian host cells. This project aims to bridge this technological gap by combining 3D printing and microfluidics technologies to spatially control the localisation of multiple …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Multi-microbial 3D printing for screening microbiome functions

The ability to 3D print bacteria has relevance to a wide range of applications, ranging from developing novel anti-microbial modalities to probiotics for promoting human health. Traditional culture techniques used in microbiology such as agar plates and suspension cultures have limited spatio-temporal control over the bacteria microenvironment as well as their interaction partners, in particular, mammalian host cells. This project aims to bridge this technological gap by combining 3D printing and microfluidics technologies to spatially control the localization of multiple …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Comprehensive strain-level characterisation of microbial communities associated with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors1,2. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD 2-5, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low phylogenetic and functional resolution. Furthermore, these studies have predominantly …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Giant viruses in the human gut microbiome

The human body is home to a vast ecosystem of microorganisms including bacteria, archaea, fungi, viruses, and bacteriophages that make up the human microbiota. These microbes and their collective genetic material, known as the microbiome, influence a wide range of physiological functions including nutrient production and absorption, the development and regulation of our immune system, protection against potential pathogens, and even our mood and mental health. While distinct microbial communities exist throughout the body, the gut microbiome has gained particular …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Dileneating immune response similarities between autoimmunity and chronic graft-versus-host disease

Project code:QIMR04Area of Research:CancerProject aims and objectives:Chronic graft-versus-host disease (GVHD) occurs in approximately 60-80% of long-term survivors of allogeneic stem cell transplantation (allo-SCT). This immunological complication is a major cause of morbidity and accounts for approximately one-quarter of the deaths in long-term transplant survivors. Clinical manifestations of chronic GVHD such as dry eyes, dry mouth and connective tissue disease closely resemble those of autoimmune disorders such as Sjogren's syndrome. Focal lymphocytic infiltrates of exocrine tissues (eg salivary glands), a characteristic …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Ruminant digestion of temperate, sub-tropical, and tropical fodders

The nutritional value of fodder, a type of animal feed, varies depending on the climate in which it is produced (i.e., temperate, sub-tropical, and tropical). The reasons for these differences has not been fully explained.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Biology and Environmental Science
Research centre(s)

Adaptive evolution of anaerobic methanotrophic (ANME) archaea mediating methane oxidation in freshwater environments

The as-yet-uncultured archaeal lineage Methanoperedenaceae are anaerobic methanotrophs with a key role in mitigating the atmospheric release of methane in freshwater environments. The metabolic diversity of these microorganisms directly links methane with several key biochemical cycles and suggests a remarkable ability of these microorganisms to adapt to diverse environmental conditions. The overall aim of this PhD project will be to uncover the metabolic diversity of the Methanoperedenaceae and to understand the evolutionary mechanisms responsible for these adaptations.Approaches/skills and techniquesThe project …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Microbial electrolysis

Microbial electrolysis has been shown to produce hydrogen in substantial amounts, which in turn can be utilised as a carbon-neutral source of energy. However, it is cost-prohibiting to use reagent-grade chemicals as a carbon source for this process. Therefore, low-cost sustainable alternatives are needed. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Defining human immune responses to a healthy gut microbiome

Many human diseases are thought to involve interactions between the gut microbiome and the immune system which shape the nature and function of immunity. These interactions between host and environment are thought to be critical regulators of health and disease. In autoimmune diseases many studies have associated presence or absence of particular microbial species with diseases and some studies have shown influence of disease-related genetics on the composition of the gut microbiome. However, no studies to date have formally addressed …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

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