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Found 16 matching student topics

Displaying 1–12 of 16 results

Metabarcoding analysis of microbiota in pasture grasses

Pasture dieback has afflicted a wide range of grasses across Queensland and New South Wales, causing immense economic damage.To help better understand this dieback, you will analyse the microbiome of grasses from field plots and controlled laboratory experiments using 16S amplicon metabarcoding.You will work as part of a larger team studying pasture dieback at QUT.

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Using machine learning to understand how the world’s microbiomes are changing due to climate

Shotgun metagenomic sequencing has become commonplace when studying microbial communities and their relationship with the health of our planet, and their direct effects on our own health. Currently, there are >180,000 shotgun metagenomes publicly available, but until recently trying to treat these data as a resource has been challenging due to its extreme size (>700 trillion base pairs).Recently we have developed a tool that can efficiently convert this base pair information into a straightforward assessment of which microorganisms are present …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Improving human health through the microbiome

Every person harbours a unique collection of microorganisms - the majority of which reside in the gastrointestinal tract - that influences nearly every aspect of human health. As such, the gut microbiome is emerging as a potential tool for the diagnosis and treatment of a wide range of diseases.However, microbiome studies yield vast amounts of data, and the complexity of the microbiome makes it difficult to decipher interactions between microorganisms, host cells and environmental factors.

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

The role of vaginal co-infections in pregnancy and neonatal outcomes

Group B Streptococcusi (GBS; Streptococcus agalactiae) is a leading pathogen that is responsible for neonatal meningitis and sepsis. Up to 40% of pregnant women have asymptomatic vaginal colonisation, and this can lead to chorioamnionitis, premature rupture of membranes and urinary tract infections, while vertical transmission from mother to baby can cause pneumonia, meningitis, sepsis and death of the neonate.There is increasing evidence that reproductive tract coinfections withGBS are occurring (eg. HSV, Candida albicans, Mycoplasma spp.), and maycontribute to poor pregnancy …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Symbiosis in microbial ecosystems

Soil systems are fundamentally important to the health of our planet, but the complexity of soil microbial communities makes them particularly challenging to study. Soil systems are amongst the most diverse microbial ecosystems on Earth in terms of the number of microbial species (and strains) present within individual samples, and in the breadth of functions encoded. Beyond complexity measured by counting distinct community members, interactions between microbial species including symbiosis, parasitism or commensalism are widespread and yet barely studied.

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Identifying emergent ecosystem responses through genes-to-ecosystems integration at Stordalen Mire

Permafrost thaw induced by climate change is predicted to make up to 174 Pg of near-surface carbon (less than 3m below the surface) available for microbial degradation by 2100. Despite having major implications for human health, prediction of the magnitude of carbon loss as carbon dioxide (CO2) or methane (CH4) is hampered by our limited knowledge of microbial metabolism of organic matter in these environments.Genome-centric meta-omic analysis of microbial communities provides the necessary information to examine how specific lineages transform …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Giant viruses in the human gut microbiome

The human body is home to a vast ecosystem of microorganisms including bacteria, archaea, fungi, viruses, and bacteriophages that make up the human microbiota. These microbes and their collective genetic material, known as the microbiome, influence a wide range of physiological functions including nutrient production and absorption, the development and regulation of our immune system, protection against potential pathogens, and even our mood and mental health. While distinct microbial communities exist throughout the body, the gut microbiome has gained particular …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Comprehensive strain-level characterisation of microbial communities associated with inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors 1,2. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD 2-5, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression.Previous IBD studies have been largely limited to older sequencing methods with low phylogenetic and functional resolution. Furthermore, these studies have predominantly …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Development of a multiplexed gut micro-bioreactor for functional screening of gut microbiome

The human microbiome refers to the collection of micro-organisms that are living symbiotically in the human body (defined as the “microbiota”), their genetic material as well as the surrounding environmental habitat.It is now appreciated that the microbiome plays an important role in human health and diseases. Various disease states have been linked to dysregulation of the gut microbiota, including neurodegenerative, cardiovascular and metabolic diseases. The composition of the gut microbiome can also affect responses to therapies, most notably in cancer …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies
Centre for Microbiome Research

Multi-microbial 3D printing for screening microbiome functions

The ability to 3D print bacteria has relevance to a wide range of applications, ranging from developing novel anti-microbial modalities to probiotics for promoting human health. Traditional culture techniques used in microbiology such as agar plates and suspension cultures have limited spatio-temporal control over the bacteria microenvironment as well as their interaction partners, in particular, mammalian host cells. This project aims to bridge this technological gap by combining 3D printing and microfluidics technologies to spatially control the localisation of multiple …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences

Strain-level characterisation and visualisation of microbial communities associated with inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low resolution. Furthermore, these studies have predominantly focused on bacterial populations, …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences

Probing the origins of life on Earth

The history of life on Earth is written in the fossil record. In this project, you will investigate stable isotope evidence for extremely early evolving organisms. Through careful petrography and with the use of isotope ratio mass-spectrometers, you will help unravel the history of microbial metabolisms that powered the ecosystems recorded by 3 billion-year-old microbial fossils.

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Earth and Atmospheric Sciences

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