QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 9 matching student topics
Displaying 1–9 of 9 results
Modelling the osteoid: A quantitative experimental–mathematical platform for osteocyte network formation and transport
Project Reference: #4MPQC-NATP3Preferred Project Start: Late 2026/Early 2027How does a newly formed bone matrix develop into a mineralised tissue containing a functional osteocyte network, and how does this transformation affect the movement of nutrients and signals?During bone formation, osteoblasts produce a soft, initially unmineralised extracellular matrix known as osteoid. Some osteoblasts gradually become embedded within this matrix and transition into osteocytes, extending dendritic processes that connect them into an intricate three-dimensional network. As the osteoid matures and mineralises, its architecture, …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
A 3D mechanosensing platform for senescent osteocytes in aging bone
Project Reference: #3MPQC-NATP2Preferred Start: Late 2026/Early 2027How do our bones sense movement, and why does this ability decline as we age?Osteocytes are specialised cells embedded throughout bone that detect mechanical forces generated during movement and exercise. They form an interconnected cellular network that helps coordinate the continuous renewal and repair of bone.With age, some osteocytes become senescent: damaged cells that remain within the tissue but no longer function normally. Their accumulation may disrupt how bone senses mechanical loading and contribute …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Engineering 3D osteocyte–tumour microenvironments to study bone metastasis and therapeutic response
Project Reference: #2MPQC-HuECM1Preferred Project Start: Late 2026/Early 2027How do cancer cells communicate with bone cells, and can we recreate these interactions in the laboratory to improve therapy testing?When cancer spreads to bone, tumour cells enter a highly specialised microenvironment containing multiple cell types and a complex extracellular matrix. Osteocytes are embedded throughout this matrix and form an interconnected cellular network that senses and regulates changes within bone. However, their contribution to cancer progression and treatment response remains poorly understood.Conventional two-dimensional …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Understanding cellular-spatial interplay between osteocyte networks and their environment using bioengineered 3D bone models
Project Reference: #1MPQC-NATP1Preferred Project Start: ImmediateHow do bone-forming cells communicate to build and maintain a functional bone matrix?Osteoblasts produce new bone extracellular matrix, while osteocytes become embedded within this matrix and form an interconnected network that helps regulate bone formation, adaptation and remodelling. Although these cells work closely together in the body, their interactions are difficult to reproduce and investigate using conventional two-dimensional cell culture.Bone-cell behaviour is strongly influenced by the surrounding microenvironment, including its composition, mechanical properties, mineral content, …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Smart composite scaffolds for bone repair
Millions of people suffer bone loss each year through cancer excisions, traumatic accidents and congenital birth defectsThis project will develop advanced bioactive composite scaffolds to heal bone defects using a technology terms melt electrowriting. You will use a special kind of 3D printing to create scaffolds that stimulate bone cells (osteoblasts) to create new bone and will optimise the formulation, size, shape and culture conditions for the scaffolds.
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Centre for Biomedical Technologies
Characterizing effects of radiation therapy in 3D bioengineered cancer models
Radiation therapy (RT) is one of the most commonly used modalities in cancer treatment, usually delivered in combination with surgical intervention, chemotherapy, and immunotherapy.However, clinical outcomes show that almost 20% of patients fail to achieve targeted outcomes because of inherent resistance to radiation. This necessitates in-depth understanding of radiation resistance mechanisms using relevant preclinical models of RT. Previous in vitro studies have predominantly used two-dimensional (2D) cell culture models that do not recapitulate the three-dimensional (3D) complexity of native tissues.
- Study level
- Honours
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Biomedical Technologies
Engineering bioartificial extracellular tumour microenvironments for Osteosarcoma personalised precision oncology
Osteosarcoma (OS) is the most common malignant bone tumour affecting children and adolescents. Importantly, clinical outcomes have not improved for decades, and bone tumours remain to be a leading cause of cancer-related death in adolescents.By identifying ideal treatment approaches for each individual patient, precision oncology has the potential to significantly improve these outcomes. Yet, its widespread application is hindered by a lack of biomaterials that support the reproducible and robust generation of patient-derived osteosarcoma organoids in vitro.Therefore, this project will …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
‘race for the surface’: designing the next generation antimicrobial biomaterials
When a biomaterial is implanted into the body and bacteria get into the implantation site, both the bacteria and tissue cells actively seek to establish their colonization on the biomaterial surface. This process, called ‘the race for the surface’ by Anthony Gristina in 1987, is still a subject of intense investigation. It is generally accepted that a biomaterial’s success in integrating with the body depends on if tissue cells win or the bacteria win the race. However, evidence from the …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Business and Law
- School
- School of Accountancy
Lignocellulose-derived innovative nanomaterials for enhancing (bio)polymer composites
Lignocellulosic biomass, such as sugarcane bagasse and rice husk, is an abundant and low-cost bioresource for producing nanomaterials such as nanocellulose, lignin nanoparticles, and nanosilica. This PhD project aims to develop cost-effective biomass processing strategies to produce innovative nanomaterials with tunable properties from lignocellulosic biomass, enhancing the performance of (bio)polymer composites in different applications.
- Study level
- PhD
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
- Research centre(s)
- Centre for Agriculture and the Bioeconomy
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