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Investigating DNA repair mechanisms in aging adult stem cells

When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2). However, we still lack a clear understanding on how the decrease in DNA …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

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