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Optimisation of nanostructured features for enhanced antibacterial response

Inspired from the insect wing nanostructures, we have fabricated several surfaces that have efficiently killed bacterial cells. However, small changes in nanoscale features immensely affects the bacterial killing rate. There is a need to optimise certain parameters in the fabrication step such that an enhanced bacterial killing rate is achieved.

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Information Systems

Optimisation of nanostructured features for antimicrobial activity

Inspired from the insect wing nanostructures, we have fabricated several surfaces that have efficiently killed bacterial cells.However, some smart changes in nanoscale features immensely affect the bacterial killing rate.There is a need to optimise certain parameters in the fabrication step to enhance the bacterial killing rate.

Study level
Master of Philosophy
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

New antimicrobials and biofilm eradication agents

Bacteria can readily adhere to the surface of synthetic materials and form a biofilm. This makes it much more difficult to combat than circulating bacteria due to their extreme resistance to antibiotics. Thus, biofilms are of particular concern in the healthcare system, as they can increase infection rates by contaminating medical devices, delay chronic wound healing and contribute to tooth decay. This project aims to design, develop and evaluate new antimicrobial compounds active against biofilms. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Genus Caloramator, model thermoanaerobes for studies on speciation and biofilm development in the Great Artesian Basin ecosystem

The Great Artesian Basin (GAB) is the largest, multilayered, deep and naturally heated subsurface aquifer in the world (storage capacity of 1012m3) which provides the outback communities with an important water resource. The GAB has five stratified layers of different geological ages and in between these layers is the flowing aquifer waters. These aquifers are recharged along the Eastern Queensland Great Dividing Range from rain water percolation and flows underground at an average flow rate of 1 -2 m/yr until …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Earth, Environmental and Biological Sciences

New anti-biofilm agents for biomedical implants

The diatomic free radical nitric oxide is a well-recognised signaling molecule in mammals which modulates bacterial existence between planktonic and biofilm modes.Low non-toxic concentrations of nitric oxide disperse a variety of Gram positive and Gram negative bacterial biofilms to free swimming planktonic bacteria.We have recently shown that nitroxides (sterically hindered versions of nitric oxide) can inhibit bacterial biofilm formation and disperse existing biofilms.

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

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