QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 66 matching student topics
Displaying 61–66 of 66 results
Understanding the genetics of melanoma susceptibility: many roads lead to DNA repair
Repair of the damage caused by mutagens such as UV and reactive oxygen species is vital to prevent cancer and premature aging and accordingly cells have developed a suite of intricate and specific DNA repair pathways. Loss or abnormal function of components of these pathways lead to cancer pre-disposition syndromes for example breast cancer in individuals carrying mutations in the BRCA1 or BRCA2 genes. Understanding the complexities of these DNA repair pathways is vital to efforts aimed at preventing or …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterising drivers of melanoma cell heterogeneity
Tumour cell heterogeneity is linked to tumour progression through the generation of divergent cellular behaviours such as proliferation, survival, invasion and therapy resistance. Crucially, conventional and targeted therapies generally only target highly proliferative cells in tumours leading to initial tumour regression, however alternative sub-populations underpin the return of treatment refractory disease and facilitate metastatic spread. Our laboratory is focused on understanding the regulatory drivers of cellular plasticity in melanoma to better understand progression and metastatic spread of this disease and …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Defining human immune responses to a healthy gut microbiome
Many human diseases are thought to involve interactions between the gut microbiome and the immune system which shape the nature and function of immunity. These interactions between host and environment are thought to be critical regulators of health and disease.In autoimmune diseases many studies have associated presence or absence of particular microbial species with diseases and some studies have shown influence of disease-related genetics on the composition of the gut microbiome. However, no studies to date have formally addressed the …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Immunotherapy for autoimmune disease using T cell receptor-modified T-regulatory cells (PhD)
Autoimmune diseases affect approximately 5% of Australians. Well known examples include type I diabetes, multiple sclerosis and rheumatoid arthritis. These diseases have unpleasant, and sometimes tragic, consequences for the affected person and are a costly burden on our health system. As treatment is often limited to managing symptoms, new therapies for autoimmune diseases are much desired.The autoimmune diseases we study are described as "organ-specific", which means the unwanted immune response attacks either a single organ, or a collection of organs …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
The interplay between environmental and genetic risk factors in the etiology of mental health disorders
Mental health disorders (e.g., depression, anxiety, substance use) are the leading cause of global disease burden in the young adult population. Twin and family studies show that both genetic and environmental factors play a large role in the aetiology of these disorders. The Translational Neurogenomics group aims to identify genetic risk factors for a range of mental health and substance use disorders, and investigate the interplay between genetic and environmental risk factors.UK Biobank is a major national and international health …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
The role of genetics in the development and mechanism of human traits
The Statistical and Genomic Epidemiology Laboratory (SGEL) studies the role of genetics in the development and mechanism of human traits, with particular emphasis on migraine, and the specific goal of identifying genetic risk factors and detecting common genetic links with other disorders, in particular depression, endometriosis, and epilepsy.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
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