Professor Travis Klein
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Biography
Professor Travis Klein is the Director of the Centre for Biomedical Technologies and the leader of the Cartilage Regeneration Laboratory (CRL) at Queensland University of Technology (QUT).The Centre for Biomedical Technologies aims to deliver better health in our lifetime, by improving how we treat complex medical cases stemming from injuries, infection and age-related issues. Our research and development focuses on better patient treatments and quality of life into the future using regenerative approaches, robotics and artificial intelligence, and advanced manufacturing to expand surgical possibilities and reduce complications.
The ultimate aim of the CRL is to help develop long-term regenerative therapies for treating cartilage defects, including osteoarthritis. To help understand chondrogenesis and joint pathologies, and engineer functional tissues, Travis' group is developing:
- functionalised biomaterials
- 3D cell culture systems
- biofabrication approaches
- mechanical stimulation technologies
In addition, the CRL works towards advancing imaging technologies for monitoring changes in native and engineered tissues. One particular area of interest has been in understanding the differences between chondrocytes and extracellular matrix of different depth zones, and recapitulating these in vitro.
Google Scholar link: http://scholar.google.com.au/citations?user=RYS5blIAAAAJ
Personal details
Positions
- Professor
Faculty of Engineering,
School of Mech., Medical & Process Engineering- Kelvin Grove Q Block Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Science and Engineering Projects - Kelvin Grove Q Block Membership
Keywords
cartilage, biofabrication, osteoarthritis, regenerative medicine, stem cells, tissue engineering, mechanobiology, biomaterials
Discipline
Biomedical Engineering, Clinical Sciences, Biochemistry and Cell Biology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- PhD (Bioengineering) (University of California)
Teaching
Travis is the Unit Coordinator for EGH438 - Biomaterials and also is a lecturer in EGB121 - Engineering Mechanics.
Publications
- Levett P, Melchels F, Schrobback K, Hutmacher D, Malda J, Klein T, (2014) A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate, Acta Biomaterialia, 10 (1), pp. 214-223.
- Loessner D, Meinert C, Kammerer E, Martine L, Yue K, Levett P, Klein T, Melchels F, Khademhosseini A, Hutmacher D, (2016) Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms, Nature Protocols, 11 (4), pp. 727-746.
- Malda J, Schuurman W, Levett P, Pot M, Van Weeren P, Dhert W, Hutmacher D, Melchels F, Klein T, (2013) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs, Macromolecular Bioscience, 13 (5), pp. 551-561.
- Melchels F, Domingos M, Klein T, Malda J, Bartolo P, Hutmacher D, (2012) Additive manufacturing of tissues and organs, Progress in Polymer Science, 37 (8), pp. 1079-1104.
- Klein T, Chaudhry M, Bae W, Sah R, (2007) Depth-dependent biomechanical and biochemical properties of fetal, newborn, and tissue-engineered articular cartilage, Journal of Biomechanics, 40 (1), pp. 182-190.
- Pahoff S, Meinert C, Bas O, Nguyen B, Klein T, Hutmacher D, (2019) Effect of gelatin source and photoinitiator type on chondrocyte redifferentiation in gelatin methacryloyl-based tissue-engineered cartilage constructs, Journal of Materials Chemistry B, 7 (10), pp. 1761-1772.
- Klein T, Schumacher B, Schmidt T, Li K, Voegtline M, Masuda K, Thonar E, Sah R, (2003) Tissue engineering of stratified articular cartilage from chondrocyte subpopulations, Osteoarthritis and Cartilage, 11 (8), pp. 595-602.
- Bas O, Juan Pardo E, Meinert C, Baldwin J, Bray L, Wellard R, Klein T, Hutmacher D, (2017) Biofabricated soft network composites for cartilage tissue engineering, Biofabrication, 9 (2), pp. 1-15.
- Levett P, Melchels F, Schrobback K, Hutmacher D, Malda J, Klein T, (2014) Chondrocyte redifferentiation and construct mechanical property development in single-component photocrosslinkable hydrogels, Journal of Biomedical Materials Research - Part A, 102 (8), pp. 2544-2553.
- Klein T, Malda J, Sah R, Hutmacher D, (2009) Tissue engineering of articular cartilage with biomimetic zones., Tissue Engineering, Part B: Reviews, 15 (2), pp. 143-157.
QUT ePrints
For more publications by Travis, explore their research in QUT ePrints (our digital repository).
Awards
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2011
- Details
- Fellowship Type: ARC Principal Research FellowshipProject Title: Regenerating articular cartilage with smart hydrogels and fabrication technologiesExternal Reference : FT110100166Years Awarded: 2011 - 2015Total Funding Awarded: $639,288
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2008
- Details
- DP0878365- APD (2008-2010)Australian Postdoctoral Fellowship (APD) "Engineering Articular Cartilage with Zonal Structure and Function"
Research projects
- Title
- ARC Industrial Transformation Training Centre for Joint Biomechanics
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100020
- Start year
- 2020
- Keywords
- Title
- ARC ITTC (CTET) for Cell and Tissue Engineering Technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100026
- Start year
- 2019
- Keywords
- Title
- A Novel Multiscale Model to Investigate Mechanical Properties of Cartilage
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP180103009
- Start year
- 2018
- Keywords
- Title
- ARC Training Centre in Additive Biomanufacturing
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC160100026
- Start year
- 2017
- Keywords
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1067108
- Start year
- 2014
- Keywords
- Cartilage Damage; Cell Differentiation; Chondrocytes; Osteoarthritis; Stem Cells
- Title
- MAPK/ERK pathway in osteoarthritis
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1032738
- Start year
- 2012
- Keywords
- osteoarthritis; pathogenesis; cell signalling; kinases; animal model
- Title
- Regenerating articular cartilage with smart hydrogels and fabrication technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT110100166
- Start year
- 2012
- Keywords
- Cartilage; Regenerative Medicine; Biofabrication
- Title
- Interplay Between Mechanical and Biological Microenvironments in Chondrocyte Function: Towards an Understanding of Cartilage Pathology
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP110103543
- Start year
- 2011
- Keywords
- Cartilage; Arthritis; Biomaterials; Lubrication; Hydrogel
- Title
- Engineering Articular Cartilage with Zonal Structure and Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0878365
- Start year
- 2008
- Keywords
- Arthritis; Cartilage; Tissue Engineering; Regenerative Medicine; Scaffold; Stem Cells
Supervision
Completed supervisions (Doctorate)
- Photocrosslinkable Hydrogels for Cartilage Tissue Engineering (2016)
- Design and Characterisation of Scaffolds for Osteochondral Regeneration (2015)
- Environments for Zonal Cartilage Tissue Engineering (2015)
- Development of Zonal Cartilage Constructs: Effects of Chondrocyte Subpopulation, Compressive Stimulation, and Culture Models (2012)
- In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences (2010)