Dr Gautam Rishi
Faculty of Health,
School of Biomedical Sciences
Biography
I obtained a PhD in Clinical Sciences from the School of Medicine, University of Queensland in 2015. During my PhD I investigated the role of transferrin receptor 2, a liver-expressed protein, in multiple physiological functions including iron homeostasis, erythropoiesis and inflammation. This project involved developing and using a variety of tissue-specific mouse models and tissue culture models.
Since 2015 I have been working as a post-doctoral researcher on a number of projects that aim to identify novel genes which play a role in maintaining iron homeostasis and understanding the function of these genes utilising cell and mice models.
I am also interested in using genomic and genetic tools to understand the development and progression of liver disease. To address this increasingly important issue I am using several novel transgenic mouse models to understand mechanisms of disease progression, next generation sequencing technologies to identify and examine the genetic factors involved in liver disease and also high throughput screening to identify natural compounds that can be used to alleviate symptoms of liver disease.
Personal details
Positions
- Visiting Associate
Faculty of Health,
School of Biomedical Sciences
Keywords
Liver disease, Fibrosis, Iron Disorders, Next Generation Sequencing, Gene editing, Cell Biology
Discipline
Biochemistry and Cell Biology, Clinical Sciences
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- Doctor of Philosophy (University of Queensland)
Professional memberships and associations
Gastroenterological Society of Australia
International Bioiron Society
Australia and New Zealand Society for Cell and Developmental Biology Inc.
The American Physiological Society
Australian Society for Biochemistry and Molecular Biology
Selected publications
- Rishi G, Subramaniam V, (2019) Signaling pathways regulating hepcidin, Vitamins and Hormones, 110, pp. 47-70.
- Hawula Z, Wallace D, Subramaniam V, Rishi G, (2019) Therapeutic advances in regulating the hepcidin/ferroportin axis, Pharmaceuticals, 12 (4).
- McDonald C, Rishi G, Secondes E, Ostini L, Wallace D, Crawford D, Sia H, Clark P, Subramaniam V, (2018) Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading, Human Genomics, 12, pp. 1-6.
- Rishi G, Secondes E, Subramaniam V, (2018) Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin, Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (8), pp. 2550-2556.
- Rishi G, Subramaniam V, (2017) The liver in regulation of iron homeostasis, American Journal of Physiology - Gastrointestinal and Liver Physiology, 313 (3), pp. 157-165.
- Rishi G, Subramaniam V, (2017) The relationship between systemic iron homeostasis and erythropoiesis, Bioscience Reports, 37 (6), pp. 1-7.
- McDonald C, Rishi G, Wallace D, Subramaniam V, (2016) Genetic variants in the BMP6 pro-peptide may not cause iron loading and should be interpreted with caution (Correspondence), Gastroenterology, 151 (4), pp. 770-771.
- Rishi G, Secondes E, Wallace D, Subramaniam V, (2016) Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia, American Journal of Hematology, 91 (8), pp. 812-818.
- Rishi G, Secondes E, Wallace D, Subramaniam V, (2016) Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2, American Journal of Physiology - Gastrointestinal and Liver Physiology, 310 (3).
- Wallace D, Secondes E, Rishi G, Ostini L, McDonald C, Lane S, Vu T, Hooper J, Velasco G, Ramsay A, Lopez-Otin C, Subramaniam V, (2015) A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction, British Journal of Haematology, 168 (6), pp. 891-901.
QUT ePrints
To find publications by Gautam, visit QUT ePrints, the University's research repository.
Research projects
- Title
- Molecular Basis and Clinical Consequences of Iron Disorders
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1024672
- Start year
- 2012
- Keywords
- Iron Metabolism; Iron Levels; Iron Overload; Anaemia; Cell Biology; Mouse Models; Knockout Mouse; Genetic Disorders
Supervision
Current supervisions
- Identification and Analysis of Genetic and Chemical Modulators of Iron Metabolism
PhD, Associate Supervisor
Other supervisors: Professor Nathan Subramaniam, Dr Daniel Wallace