Dr Abbas Shafiee
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Biography
Dr. Abbas Shafiee is a PhD specialized in stem cell biology, and tissue engineering with over 12 years combined research experience in academia and biotechnology industry. The focus of his research is to develop translational cell-based and tissue engineering approaches to treat cardiovascular and cancer diseases.Dr. Shafiee completed his PhD at The University of Queensland Centre for Clinical Research (UQCCR). His PhD study focused on the in vivo definition of endothelial progenitor cells (EPC) from the human placental tissues. As a result of this project, he established a new in vivo hierarchy amongst EPCs. He also identified the bipotential precursors, Meso-Endothelial cells, in the human placenta which programmed to give rise to both mesenchymal and endothelial stem/progenitor.
After finishing PhD, he joined Centre in Regenerative Medicine (CIRM), QUT and conducted a project on investigation of cancer bone metastasis using modelomics approach with distinguished professor Dietmar Hutmacher. At CIRM, they have developed a new cutting edge research area, humanized animal models, via the translation of tissue engineering technologies into cancer research. They have utilized the humanized animal models as platforms to study species-specific cancer bone metastasis and develop and test new therapeutic strategies.
Main research areas:
- Stem cells biology and cell therapy
- Tissue Engineering and regenerative medicine
- In vivo models for cancer metastasis including humanized mouse models
Personal details
Positions
- Visiting Fellow
Faculty of Engineering,
School of Mech., Medical & Process Engineering- Kelvin Grove Q Block Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Science and Engineering Projects - Kelvin Grove Q Block Membership
Keywords
Stem cells, Biomaterial, Modelomics, Humanized animal model, Cancer metastasis, Vascular development, Regenerative medicine, Tissue engineering, Placenta
Discipline
Biomedical Engineering, Other Physical Sciences
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- PhD (Queensland University of Technology)
Professional memberships and associations
International Society for Stem Cell Research (ISSCR)
Australasian Society for Biomaterials and Tissue Engineering (ASBTE)
Australian Society for Medical Research (ASMR)
International Federation for Placental Association (IFPA)
Australasian Society for Stem Cell Research (ASSCR)
American Heart Association (AHA)
Australasian Society for Biomaterials and Tissue Engineering (ASBTE)
Australian Society for Medical Research (ASMR)
International Federation for Placental Association (IFPA)
Australasian Society for Stem Cell Research (ASSCR)
American Heart Association (AHA)
Teaching
Cellular and Molecular Biology;
Advanced Biotechnology;
Drug Discovery and Design
Advanced Biotechnology;
Drug Discovery and Design
Publications
- Shafiee A, Patel J, Hutmacher D, Fisk N, Khosrotehrani K, (2018) Meso-endothelial bipotent progenitors from human placenta display distinct molecular and cellular identity, Stem Cell Reports, 10 (3) p890
- Shafiee A, McGovern J, Lahr C, Meinert C, Moi D, Wagner F, Landgraf M, Juan Pardo E, Mazzieri R, Hutmacher D, (2018) Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study, International Journal of Cancer, 143 (6) p1470
- Wagner F, Holzapfel B, McGovern J, Shafiee A, Baldwin J, Martine L, Lahr C, Wunner F, Friis T, Bas O, Boxberg M, Prodinger P, Shokoohmand A, Moi D, Mazzieri R, Loessner D, Hutmacher D, (2018) Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma, Biomaterials, 171 () p230
- Shafiee A, Hutmacher D, (2018) Modelomics to investigate cancer bone metastasis, Current Molecular Biology Reports, 4 (2) p88
- Sardesai V, Shafiee A, Fisk N, Pelekanos R, (2017) Avoidance of maternal cell contamination and overgrowth in isolating fetal chorionic villi mesenchymal stem cells from human term placenta, Stem cells translational medicine, 6 (4) p1070
- Shafiee A, Baldwin J, Patel J, Holzapfel B, Fisk N, Khosrotehrani K, Hutmacher D, (2017) Fetal bone marrow-derived mesenchymal stem/stromal cells enhance humanization and bone formation of BMP7 loaded scaffolds, Biotechnology Journal, 12 (12) p1
- Shafiee A, Patel J, Wong H, Donovan P, Hutmacher D, Fisk N, Khosrotehrani K, (2017) Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling, FASEB Journal, 31 (2) p610
- Patel J, Wong H, Wang W, Alexis J, Shafiee A, Stevenson A, Gabrielli B, Fisk N, Khosrotehrani K, (2016) Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling, Stem Cells, 34 (4) p902
- Shafiee A, Fisk N, Hutmacher D, Khosrotehrani K, Patel J, (2015) Fetal endothelial and mesenchymal progenitors from the human term placenta: Potency and clinical potential, Stem cells translational medicine, 4 (5) p419
- Shafiee A, Seyedjafari E, Taherzadeh E, Dinarvand P, Soleimani M, Ai J, (2014) Enhanced chondrogenesis of human nasal septum derived progenitors on nanofibrous scaffolds, Materials Science and Engineering C: Materials for Biological Applications, 40 () p445
QUT ePrints
To find publications by Abbas, visit QUT ePrints, the University's research repository.
Awards
- Type
- Funding Award
- Reference year
- 2018
- Details
- CRC for Cell Therapy Manufacturing Grant
- Type
- Assessor, Examiner or Supervisor Role
- Reference year
- 2017
- Details
- National Health and Medical Research Council grant reviewer
- Type
- Membership of Review Panels on Prestigious Grant Applications
- Reference year
- 2018
- Details
- Grant assessor for Australian Research Council (ARC)
- Type
- Membership of Review Panels on Prestigious Grant Applications
- Reference year
- 2017
- Details
- Research grant assessor for National Institute for Medical Research Development (NIMAD).
- Type
- Funding Award
- Reference year
- 2017
- Details
- ECR grant
- Type
- Editorial Role for an Academic Journal
- Reference year
- 2018
- Details
- Frontiers in Materials provides the most comprehensive thematic open-access collection of outstanding research across materials science and technology.