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Found 642 matching student topics

Displaying 433–444 of 642 results

Advanced materials for supercapacitors

Energy storage devices, such as supercapacitors, play an increasingly important role in our daily life as a reliable energy supplier. Supercapacitors are a type of energy storage system that possess merits of rapid energy storage and release (high power density) with a cycling lifetime of ten thousand or more. Nevertheless the energy density of conventional electrochemical capacitor is quite low.This project aims to enhance the energy density of supercapacitor by designing and synthesising nanostructured materials using transition metals.

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science
Centre for Clean Energy Technologies and Practices

Understanding the structure-property relationships in reduced graphene oxide hydrogels

Graphene consists of hybridised carbon atoms in a hexagonal two-dimensional (2D) lattice. This material has extraordinary mechanical, thermal and electrical properties. However, one problem in practical applications is the aggregation and restacking between neighbouring graphene layers.In contrast, a possible way to avoid this problem is by transforming 2D graphene sheets into graphene hydrogel (GH) consisting of a three dimensional (3D) porous structure. Recently, 3D GH has been widely investigated in energy storage and conversion, catalysis and sensors. Furthermore, its accessible …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Materials Science
Centre for Clean Energy Technologies and Practices

Advanced materials for perovskite solar cells

Solar cells using metal halides perovskite materials to absorb light is one of the most important scientific discoveries. These cells have the potential to provide cost-effective solar electricity in the future. In the last decades, perovskite solar cells (PSCs) demonstrated unprecedented progress towards this goal. This technology holds the world record for energy conversion efficiency and is comparable to commercial crystalline silicon, but at a much lower cost.Currently their instability and use of toxic lead are key issues that restrict …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science
Centre for Clean Energy Technologies and Practices

Investigating differences in downstream signalling mediated by two isoforms of FGFR2 in endometrial cancer

FGFR2 encodes two alternatively spliced isoforms that differ in their ligand binding domain and the combination of tissue specific expression of these isoforms and tissue specific expression of the FGF ligands is the foundation of normal paracrine signalling. Isoform switching from FGFR2b (inclusion of exon 8) to FGFR2c (inclusion of exon 9) occurs in tumorigenesis as it establishes an autocrine loop in epithelial cancer cells.We have previously published a detailed investigation into differences between wildtype FGFR2b and mutant FGFR2b following …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Metagenomic analysis of bacterial contamination screening pooled platelets

Bacterial sepsis is second only to ABO incompatibility as a cause of death from transfusion. Bacterial contamination of platelets is recognised as the most significant residual infectious risk of transfusion in developed countries. Bacterial Contamination Screening (BCS) has been required for testing of pooled and apheresis platelets manufactured by the Blood Service since April 2008. International microbiological culture studies suggest that the incidence of bacterial contamination ranges from 1:3000 to 1:1000 units of apheresis platelets and 1 in 600 to …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer

Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Nutrition interventions to improve outcomes in people with kidney dIsease

Dietary interventions are cornerstone treatment in chronic kidney disease. Our research focuses on the shift away from nutrient monitoring, and towards a whole food approach to improving diet quality and reduce disease progression. We have expertise in nutritional epidemiology and dietary intervention trials, and work directly with clinicians in patient care.We currently have projects investigating:Plant based diets to reduce resistant proteinuriaIntensive weight loss to slow progression of kidney diseaseThe impact of dietary patterns on cardiovascular disease risk in chronic kidney …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Exercise and Nutrition Sciences

Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate 'mini-tumours-in-a-dish' from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

A novel diagnostic test for lung transplant rejection – circulating cell-free methylated DNA

Lung transplantation is a complex medical procedure for those with advanced lung disease. Average survival following lung transplantation is shorter than for any other solid organ. The median survival time of a lung transplant recipient is only 8 years due to a high incidence (over 75% at 10 years) of chronic rejection (also called chronic lung allograft dysfunction – CLAD). The clinical course of CLAD is progressive with irreversible lung injury that ultimately leads to lung failure. The median survival …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer

Prostate cancer is an androgen dependent cancer and treatments are aimed at preventing activation of the androgen receptor. Part of the development of resistance to therapies involves prostate cancers reprogramming their metabolism to overcome metabolic stress induced by these therapies and support growth and survival. This reprogramming involves increases in the rate of glycolysis and intermediate pathways branching from glycolysis. Previously in our laboratory, the natural compound, beta-carboline dimer, BD, was identified to have potent effects on cell viability, cell …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Giant viruses in the human gut microbiome

The human body is home to a vast ecosystem of microorganisms including bacteria, archaea, fungi, viruses, and bacteriophages that make up the human microbiota. These microbes and their collective genetic material, known as the microbiome, influence a wide range of physiological functions including nutrient production and absorption, the development and regulation of our immune system, protection against potential pathogens, and even our mood and mental health. While distinct microbial communities exist throughout the body, the gut microbiome has gained particular …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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