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Mathematical modelling of the mechanobiology during plaque growth

Plaque growth is a chronic inflammatory response induced by the interactions between vascular endothelial cells, lipids, monocytes/macrophages, vascular smooth muscle cells and platelets in the arteries. The mechanism involves interactions between the activities of cellular and acellular components in plaque microenvironment. Experimental studies have revealed the contributing roles of many different biological factors and processes, such as:lipid depositioninflammationangiogenesishaemorrhage.Due to the difficulties in experimental measurement and visualisation of the multiscale process, and the complex nature of the local environment, these complex …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Machine learning in a very different future

Machine learning aims to make predictions about novel data based on associations and relationships from past data. This approach rests on the assumption that the past is representative of the future.We're exploring how statistical machine learning might be used knowing that aspects of the future are likely to be fundamentally different to the past that generated the historical training data.Our aim is to is to look for fruitful ways to couple simulation and inference so that we can take advantage …

Study level
Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Computer Science
Research centre(s)
Centre for Data Science

Computational modelling of liquid marbles

Liquid marbles are liquid droplets coated with super-hydrophobic particles. They possess interesting properties such as the ability to contain liquid content without wetting surfaces and enhanced elasticity.Numerous experimental studies on liquid marbles and their properties have already been reported in the literature. For example, novel microfluidic applications, miniature bioreactors and gas sensing mechanisms. Despite plenty of experimental work, there is limited computational modelling investigations of liquid marbles represented in literature.A successful numerical model would be able to derive new insights …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Development of diffusion analysis methods for characterisation of tissues and porous materials

Molecular diffusion can be used as a probe of the microstructure and organisation of materials and biological tissues.Biomedical applications of diffusion include diffusion-tensor imaging, which has been used as the basis for nerve fibre tractography in the brain, as well as microstructural imaging of tissues and materials. Diffusion measurements of tissues and biomaterials can reveal the organisation and anisotropy of their structural scaffold (e.g., collagen fibres or muscle cells).In the oil and gas industry, the diffusion propagator in porous media …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Molecular simulation of rotational diffusion in ideal liquids

Rotational tumbling of molecules in a liquid is an important phenomenon in Magnetic Resonance Imaging (MRI) because it determines the spin-relaxation rates of the resident nuclei which can determine MRI contrast.For a relatively simple molecular process, the theoretical description of rotational motion of molecules in liquids remains controversial. The most commonly used model, the Debye model, assumes that:the rotational diffusion propagator of a tumbling molecule is a solution of the diffusion equation on a spherical surfacethis solution is described by …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Laboratory simulation of Secondary Organic Aerosol (SOA) formation

This project aims to investigate the interaction of anthropogenic (human-made) emissions and biogenic emissions from plants and trees and subsequent secondary organic aerosol (SOA) production in urban environments. This is relevant as SOA is part of particulate matter (PM), which is associated with smog events in cities, affects the climate and has negative impacts on human health.SOA is formed in the atmosphere by complex reactions of volatile organic compounds (VOCs) of anthropogenic or biogenic origin with atmospheric oxidants (OH radicals, …

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Earth and Atmospheric Sciences
Research centre(s)

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

Excessive clotting (thrombosis) leads to the cardiovascular diseases such as heart attack and stroke, killing one Australian every 12 minutes. It has long been recognized that platelets play a central role in thrombosis and are unique in their ability to form stable adhesive interactions under conditions of rapid blood flow.We've recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights the remarkable platelet sensitivity to the shear stress gradients of blood flow disturbance. Importantly, we've found that current anti-thrombotic drugs, such …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Maxwell's Demon revisited: Molecular simulations as a statistical physics learning tool

In his 1871 'Theory of Heat', James Clerk Maxwell introduced a fictitious being who can violate the second law of thermodynamics by following the trajectory of every molecule within a gas.The being, later dubbed 'Maxwell's Demon' by Lord Kelvin, would operate a small trapdoor in a partitioned container to allow hotter and colder molecules of the gas to pass to opposite sides of the container. The Demon would be able to raise the temperature of the gas in one half …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)

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