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Found 8 matching student topics

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Investigating genetic variants involved in Wilson disease and copper metabolism using genome editing

Wilson disease (WD) is a genetic disorder of copper metabolism. It can present with hepatic and neurological symptoms, due to copper accumulation in the liver and brain (1). WD is caused by compound heterozygosity or homozygosity for mutations in the copper transporting P-type ATPase gene ATP7B. Over 700 ATP7B genetic variants have been associated with WD. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. Early diagnosis and treatment are important for successful management of the disease. …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

High-performance scoring of CRISPR targets

The CRISPR-Cas9 technology allows the modification of virtually any gene in any organism of interest. It's generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the "guide RNAs" that will control where modifications occur. It's vital that the modification is made at the desired location and not elsewhere.We developed a method utilising high-performance computing to efficiently assess the "off-target risk" of each guide RNA …

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Computer Science
Research centre(s)
Centre for Data Science

Visualisation of CRISPR targets

CRISPR-Cas9 technology allows us to modify virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the “guide RNAs” that will control where modifications occur.We have developed a software pipeline, named Crackling, to identify safe and effective guide RNAs across entire genomes. We're now seeking to develop a visualisation to communicate the results produced by …

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Computer Science
Research centre(s)
Centre for Data Science

Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM03)

Project code:BIOM03Project aims and objectives:Liver disease is a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism is associated with many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease.These two inter-related research themes are the focus of research in the Hepatogenomics Research Group in the School of Biomedical Sciences and IHBI; we hope to advance our understanding of these disorders at a molecular level with the …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Novel therapeutic strategies to treat advanced colorectal cancer

Colorectal cancer is a very common disease, with over 15,000 new cases diagnosed in Australia annually. Metastatic colorectal cancer describes advanced disease that has spread beyond the primary site. This is very aggressive and incurable in the vast majority of these patients. To improve outcomes for colorectal cancer, we are using cutting edge genomic and cell biology techniques to understand disease heterogeneity and optimise drug response. We are developing novel therapeutic interventions based on unique molecular signatures and are testing …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Microsatellite Instability as a determinant of chemotherapy sensitivity

Project code:QIMR07Area of Research:CancerProject aims and objectives:Colorectal cancer is a major cause of mortality in Australia. Late stage colorectal cancers usually treated with a battery of cytotoxic chemotherapeutics, including a drug called TAS-102. The efficacy of chemotherapy varies dramatically between patients due to reasons that are not entirely clear. We have evidence that microsatellite instability may influence how patients respond to TAS-102, and in this project, we will combine genome engineering using the CRISPR-Cas9 system with traditional cell culture techniques …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Jurisprudence and theories of law

Dr Alex Deagon is available to supervise students who are interested in the topics of jurisprudence, theories of law, legal philosophy, law and theology, law and religion, or religious freedom.

Study level
PhD, Master of Philosophy
Faculty
Faculty of Law
School
School of Law
Research centre(s)

Capacity, wills and enduring powers of attorney

Dr Kelly Purser is interested in talking to students who wish to undertake research on the topics of capacity, wills, enduring powers of attorney, advance health directives, estate planning, equity and trusts, succession, or therapeutic jurisprudence.

Study level
PhD, Master of Philosophy
Faculty
null
School
null
Research centre(s)
null
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