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Displaying 73–84 of 585 results

Measures of agile trust

In today's highly dynamic, opportunity-rich markets, the rapid manifestation of trust has become a major challenge for both established and new organisations that attempt to introduce new products and services. Previous research focused mainly on the long-term development of trust (e.g., concerning brand reputation), and the nature (and factors) of immediate trust decisions remain under-researched.

Study level
PhD, Master of Philosophy
Faculty
Faculty of Business and Law
School
School of Accountancy
Research centre(s)
Centre for Future Enterprise

Biophysical models in humans and nature

Biophysical models are developed to represent key processes in humans and nature, from the electrophysiology of the human heart, to calcium carbonate skeleton production of coral reefs.In this project, we will explore biophysical model development across multiple fields, to identify commonalities, strengths and weaknesses, and identify analysis techniques ubiquitous in one field that can be immediately exploited to improve science in another field.

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Exploring exosomes as potential cancer biomarkers

Aims and MethodologyOur team investigates specific mechanisms in which cancer cells communicate with the environment in order to promote disease progression. In particular, we aim to understand the processes employed by cancer-derived small extracellular vesicles, termed exosomes, to promote the spread of cancer cells from the primary site to distal organs. Additionally, our group analyses the molecular composition of exosomes isolated from the blood of cancer patients, in order to establish innovative cancer-specific signatures that will ultimately improve cancer diagnosis …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Protein biomarkers to predict immunotherapy response in lung cancers

Immunotherapy has revolutionised cancer treatment in the recent years. It has been successfully used to treat several melanoma and lung cancer patients. However, not all patients respond to immunotherapy. There is a clinical need for biomarkers that can identify lung cancer patients that are most likely to benefit from immunotherapy.In this project, we will employ mass spectrometry-based proteomics approaches to carry out proteomic profiling of mononuclear cells and plasma samples from lung cancer patients treated with immunotherapy. Proteome profiles of …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Improving therapeutic responses to chemotherapy through combination common drugs

Colorectal cancer is responsible for over 5,000 deaths each year, with most deaths resulting from the spread of cancer to distant sites. When this occurs, cancer is said to be metastatic. When colorectal cancer is metastatic, chemotherapy becomes the mainstay of treatment. Responses to chemotherapy are mixed, and resistance and progression occur in more than 95% of patients.There is a need to enhance responses to common chemotherapeutics to improve patient outcomes. This project will investigate combining common and safe compounds …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Chimeric Antigen Receptor (CAR) T cells for the treatment of cancer

Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They are a type of cancer immunotherapy that can be very effective against certain types of blood cancers and are now approved for use in patients. However, CAR T cells can only benefit a very small proportion of cancer patients at present.The aim of this project is to develop new types of CAR T cells that are more effective and can target …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Feasibility of mapping individual electroencephalography to neuroanatomical sources across children and adolescents

Aims and MethodologyBackgroundSource reconstruction of electroencephalography (EEG) in adults has become a widely used technique to derive estimated electrophysiological signal representations occurring at specific anatomical locations. Yet there remains a dearth of source-based EEG techniques in paediatric populations which feasibly and accurately capture the same representations. The availability of a streamlined source based EEG framework would provide an essential platform for neuroscientists in the paediatric research space to analyse their EEG data with respect to neuroanatomy.AimTo assess the feasibility of …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Investigation of dysregulated iron metabolism in cystic fibrosis

Cystic fibrosis is a genetic disease caused by cystic fibrosis transmembrane regulator (CFTR) mutation. CFTR protein is responsible for transporting chloride to the cells and defective CFTR leads to excessive sweat and mucus secretion mainly affecting the lungs. Cystic fibrosis lungs are prone to bacterial infection which could lead to exacerbations.High levels of iron have been reported in airways of cystic fibrosis patients and this is associated with increased bacterial infection in the patients. However, the mechanism of iron dysregulation …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Harnessing immune-mediated control of blood cancers

Immunotherapy has emerged as a new pillar in cancer treatment. Our research team is investigating how we can improve anti-tumour immune responses against blood cancers.This project is based at QIMR Berghofer (Herston).

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Investigating hepcidin regulation in hereditary haemochromatosis

Iron is an essential nutrient, but is also toxic when in excess, so the amount of iron in the body must be tightly controlled. As mammals don’t actively excrete iron, body iron levels are regulated at the point of absorption in the small intestine. This process is controlled by the hormone hepcidin which is secreted by the liver in response to iron requirements.Circulating hepcidin binds to the iron export protein ferroportin on intestinal cells, causing the protein complex to be …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Deploying student voice to improve engagement and learning

Reform to address barriers to learning for students with disability, at all levels of education, is required by international human rights law and national anti-discrimination legislation. Such reform can be achieved through the application of universal design principles to pedagogy, curriculum and assessment; a process with the potential to improve the comprehension, engagement and learning of all students, as well as reduce academic workload by generating fewer requests for clarification.This collaborative project between academics in the School of Accountancy, Faculty …

Study level
Vacation research experience scheme
Faculty
Faculty of Business and Law
School
School of Accountancy
Research centre(s)

Centre for Inclusive Education

Prolonging survival in brain cancer by targeting slow-dividing cells

Aims and MethodologyGlioblastoma (GBM) is the most common and malignant primary brain tumour in adults. GBM is deadly because of resistant glioma stem cells that reconstitute the tumour after treatment. Glioma stem cells resist chemotherapy in part because they are quiescent (slow-dividing), whereas chemotherapy primarily targets fast-dividing cells. In this project we will test targeted molecules to inhibit quiescence, forcing glioma stem cells to divide during chemotherapy to prevent tumour recurrence.Applicants can expect to gain experience in tissue culture, microscopy, …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

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