QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 34 matching student topics
Displaying 13–24 of 34 results
Investigating immunosuppression downstream of activated FGFR2 in endometrial cancer
FGFR2 encodes two alternatively spliced isoforms that differ in their ligand binding domain and the combination of tissue specific expression of these isoforms and tissue specific expression of the FGF ligands is the foundation of normal paracrine signalling. Isoform switching from FGFR2b (inclusion of exon 8) to FGFR2c (inclusion of exon 9) occurs in tumorigenesis as it establishes an autocrine loop in epithelial cancer cells. Our lab has reported that FGFR2 activation by mutations or isoform switching is associated with …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Should Australia legislate to allow three parent babies?
In 2015, the United Kingdom legalised a form of in vitro fertilisation (IVF) therapy known as ‘three-parent IVF’ and, less colloquially, mitochondrial replacement therapy (MRT). This IVF procedure is aimed at enabling women who have mitochondrial diseases that would normally be passed down to their offspring to have a healthy child instead. The technique involves removing faulty mitochondria from the intended mother’s egg and replacing them with mitochondria from a generically unrelated woman (by transferring the intended mother's nucleus to …
- Study level
- PhD
- Faculty
- Faculty of Business and Law
- School
- School of Law
- Research centre(s)
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Australian Centre for Health Law Research
Medication and dietary supplement use and symptom severity of chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is highly prevalent and clinically problematic, occurring in up to 60–80% of people receiving chemotherapy. Despite the high prevalence and significant patient and healthcare burden of CIPN, treatment options are limited.This project will explore the association between medication and dietary supplement use and symptom severity of CIPN to identify factors that might worsen or improve CIPN symptoms.
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Nursing
- Research centre(s)
- Centre for Healthcare Transformation
Cancer and Palliative Care Outcomes Centre
CLIN02 - Exploring the creation of an integrated communication curriculum within the Radiation Therapy undergraduate program
Radiation Therapy graduates are required to demonstrate effective communication skills with patients, their families and members of the health care team in the provision of high quality patient care. This aligns with Course Learning Outcome 3: Graduates will have the communication and interpersonal skills necessary to enhance clinical practice in relation to the welfare of patients and interaction with colleagues and the wider community. This requirement is further evidenced through Domain 3 of the MRPBA Professional Capabilities for Medical Radiation …
- Study level
- Vacation research experience scheme
- Faculty
- Faculty of Health
- School
- School of Clinical Sciences
Spatial profiling of the tumour microenvironment
Lung cancers are the leading cause of cancer related deaths in Australia, with a 5-year survival of 15%. With the emerging success of immune checkpoint blockage leading to durable responses and prolonged survival in 15-40% of cases, there is now a need for predictive biomarkers to guide selection for immunotherapies.The immune contexture of the tumour microenvironment (TME) is an important factor in dictating how well a tumour may respond to immune checkpoint therapies (1). Spatial and immunological composition with cellular …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Novel therapeutic strategies to treat advanced colorectal cancer
Colorectal cancer is a very common disease, with over 15,000 new cases diagnosed in Australia annually. Metastatic colorectal cancer describes advanced disease that has spread beyond the primary site. This is very aggressive and incurable in the vast majority of these patients. To improve outcomes for colorectal cancer, we are using cutting edge genomic and cell biology techniques to understand disease heterogeneity and optimise drug response. We are developing novel therapeutic interventions based on unique molecular signatures and are testing …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Immunotherapy for autoimmune disease using T cell receptor-modified T-regulatory cells (PhD)
Autoimmune diseases affect approximately 5% of Australians. Well known examples include type I diabetes, multiple sclerosis and rheumatoid arthritis. These diseases have unpleasant, and sometimes tragic, consequences for the affected person and are a costly burden on our health system. As treatment is often limited to managing symptoms, new therapies for autoimmune diseases are much desired.The autoimmune diseases we study are described as "organ-specific", which means the unwanted immune response attacks either a single organ, or a collection of organs …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Exploring chemotherapy-induced molecular aging and its relationship to exercise
Ovarian cancer is the sixth most common cause of death from cancer in women, with a five-year survival rate of less than 45 per cent. However, there is emerging research that shows the benefits of exercise therapy during recovery following certain cancer treatments, and how exercise can improve and extend the lives of women with ovarian cancer.This project is a collaboration exploring these health and survival outcomes in ovarian and other gynaecological cancers, and in particular how new diagnostic testing …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Improving platinum-based chemotherapy by targeting drug metabolism in lung cancer
Lung cancer is the deadliest cancer accounting for 18.4% of all cancer-related deaths. Platinum-based chemotherapy remains a key treatment option for most people living with this disease, either as adjuvant therapy or in combination with immunotherapy. However, resistance to therapy is a significant issue in the treatment of lung cancer. Novel therapeutic strategies combined with predictive biomarkers chemotherapy response are needed to transform the clinical management of NSCLC.Our published work has identified novel biomarkers and druggable proteins from deregulated protein …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
Capacity, wills and enduring powers of attorney
Dr Kelly Purser is interested in talking to students who wish to undertake research on the topics of capacity, wills, enduring powers of attorney, advance health directives, estate planning, equity and trusts, succession, or therapeutic jurisprudence.
- Study level
- PhD, Master of Philosophy
- School
- null
- Research centre(s)
- null
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