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A preclinical evaluation pipeline for new antivirulence drugs targeting multidrug resistant bacterial pathogens

A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.’ - WHO, 2014 (1). Antimicrobial resistance (AMR) is a global public health priority. If no action is taken, AMR is predicted to kill more people than cancer and diabetes combined by 2050, with 10 million deaths estimated each year and a global cost of up to 100 trillion USD. New therapies to tackle multidrug …

Study level
Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Understanding and manipulating bacterial motility for infection control

The recent COVID 19 pandemic reminds us of how difficult it is to control infectious diseases. Pathogenic microorganisms are known to be extremely 'smart' and are able to quickly develop mechanisms against most of our strategies aimed at eradicating them. Our group is focused on bacterial infections to implants and medical devices. We are in the pursuit to outsmart the bacteria to develop the next generation medical device and implant materials.Bacterial motility/movement and group-coordination on surfaces and in 3-dimensional environment …

Study level
PhD
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Understanding and manipulating bacterial motility for infection control (PhD)

The recent COVID 19 pandemic reminds us of how difficult it is to control infectious diseases. Pathogenic microorganisms are known to be extremely 'smart' and are able to quickly develop mechanisms against most of our strategies aimed at eradicating them. Our group is focused on bacterial infections to implants and medical devices. We are in the pursuit to outsmart the bacteria to develop the next generation medical device and implant materials.Bacterial motility/movement and group-coordination on surfaces and in 3-dimensional environment …

Study level
PhD
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Race for the surface: helping implants to win the race

The recent COVID-19 pandemic reminds us of how difficult it is to control infectious diseases. Pathogenic microorganisms are known to be extremely 'smart' and are able to quickly develop mechanisms against most of our strategies aimed at eradicating them.Our group is focused on bacterial infections to implants and medical devices. We are in the pursuit to outsmart the bacteria to develop the next generation medical device and implant materials.When a biomaterial is implanted into the body and bacteria get into …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Bacteria - mammalian cell interactions in implant-associated infections

The recent COVID-19 pandemic reminds us of how difficult it is to control infectious diseases. Pathogenic microorganisms are known to be extremely 'smart' and are able to quickly develop mechanisms against most of our strategies aimed at eradicating them. Our group is focused on bacterial infections to implants and medical devices. We are in the pursuit to outsmart the bacteria to develop the next generation medical device and implant materials.Anthony Gristina conceptualized in 1987 that bacteria compete with tissue cells …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Can virus-based defective interfering particles (DIPS) be used to treat dengue infection?

Infection by dengue virus causes incapacitating and potentially dangerous acute disease in humans. Dengue is a mosquito-borne infectious disease with about 100 million serious clinical infections annually. Considerable effort in drug development is underway, but no effective drug therapy is available. A major difficulty for drug development is the rapid evolution of RNA viruses, like dengue virus, which presents a major challenge for controlling virus transmission and infection using conventional pharmaceuticals and vaccines.This project is based on the observation that …

Study level
Master of Philosophy
Faculty
1043076
School
School of Biomedical Sciences

Infection kinetic changes that occur within macrophage-adapted Chlamydia

Chlamydia trachomatis is an obligate intracellular, bacterial pathogen. C. trachomatis infections of the human reproductive tract affect approximately 127 million people globally each year. The major concern of C. trachomatis infections is their ability to cause infertility in both men and women, by damaging the upper reproductive tracts. However, we are still lacking information about how Chlamydia travels around the reproductive tract, and reaches the upper tract (ovaries and testes in particular) to cause this damage.Recent research has shown that …

Study level
Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Characterisation of emerging multidrug resistant E. coli pathogens

The last fifteen years have witnessed an unprecedented rise in the rates of antimicrobial resistance among Gram-negative bacteria, described by the World Health organisation as a global health crisis (1). Escherichia coli sequence type 131 (E. coli ST131) is a ‘high-risk’ group of Gram-negative pathogens that have emerged rapidly and spread worldwide in the period of the last 10 years (2). E. coli ST131 strains are typically resistant to multiple classes of antibiotics and cause bloodstream and urinary tract infections …

Study level
Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Understanding capsular polysaccharide diversity is key to next generation therapies for multi-drug resistant Acinetobacter baumannii infections

Bacteriophage therapy is an attractive innovative treatment for infections caused by extensively drug resistant Acinetobacter baumannii, for which there are few effective antibiotic treatments remaining.Capsular polysaccharide (CPS) is a primary receptor for lytic bacteriophage, thus knowledge of the chemical structures of CPS produced by the species underpins the identification of suitable phage for therapeutic cocktails.As many phage depolymerases cleave a specific CPS linkage formed by either a glycosyltransferase or polymerase enzyme, characterisation of these proteins are essential.However, these remain largely …

Study level
PhD
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

The role of vaginal co-infections in pregnancy and neonatal outcomes

Group B Streptococcusi (GBS; Streptococcus agalactiae) is a leading pathogen that is responsible for neonatal meningitis and sepsis. Up to 40% of pregnant women have asymptomatic vaginal colonisation, and this can lead to chorioamnionitis, premature rupture of membranes and urinary tract infections, while vertical transmission from mother to baby can cause pneumonia, meningitis, sepsis and death of the neonate.There is increasing evidence that reproductive tract coinfections withGBS are occurring (eg. HSV, Candida albicans, Mycoplasma spp.), and maycontribute to poor pregnancy …

Study level
PhD, Master of Philosophy
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Chronic toxoplasma gondii infection and degenerative diseases of the brain and retina

This project will test the central hypothesis that chronic Toxoplasma gondii infection contributes to degenerative diseases of the brain and retina. T. gondii is a protozoan parasite that is estimated to infect ~30% of the world’s population. The parasite invades the brain and retina, where it converts into a slowly-replicating form within a cyst. These cysts can remain latent (chronic infection) for the life of the individual without reactivation or causing clinical symptoms. However, there is increasing evidence from human …

Study level
Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

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