QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 90 matching student topics
Displaying 1–12 of 90 results
CGPH01 - Human neural stem cell models to understand neurogenesis and neurodegeneration
Neurodegenerative disorders such as Alzheimer’s Disease continue to impact the quality of life of a significant number of Australians, yet they remain untreatable. If we focus on how human neural stem cells behave normally and compare them to similar cells from Alzheimer’s patients, we will likely gain a better understanding of what has gone wrong and potentially how to stop it or fix it.
- Study level
- PhD, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
HoliCOW – A holobiont strategy to decipher core host-microbiota interactions in cows
To meet the goal of limiting global warming to 1.5C, methane emissions from ruminants such as beef and dairy cattle must be reduced by 11–30% by 2030 and by 24–47% by 2050 compared to 2010 levels. A newly funded Future Fellowship project is hiring 2 PhD students who will tackle this challenge by creating a thorough mechanistic understanding of the microbiological, biochemical and genetic processes that cause methanogenesis in the cow rumen. These activities will identify core beneficial microbiota that …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Therapeutic opportunities targeting epigenetic-metabolism crosswalks in cancer
Epigenetic and metabolic pathways in cancer cells are highly interconnected. Epigenetic landscape in cancer cells is modified by oncogene-driven metabolic changes. Metabolites modulate the activities of epigenetic modifying enzymes to regulate the expression of specific genes. Conversely, epigenetic deregulation that occurs in cancer affect the expression of metabolic genes, thereby altering the metabolome. These changes all coordinately enhance cancer cell proliferation, metastasis and therapy resistance.The overall aim of the project is to understand the link between the activity of epigenetic …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Epigenetic regulation of non-coding RNAs in hypoxic tumours
In solid tumours, hypoxia occurs as a result of limitation on oxygen diffusion in avascular primary tumours or their metastases. Persistent hypoxia, significantly reduces the efficacy of radiation and chemotherapy and lead to poor outcomes. This is mainly due to increase in pro-survival genes that suppress apoptosis, enhance tumour angiogenesis, the epithelial-to-mesenchymal transition, invasiveness and metastasis. Much of tumour hypoxia research has been centred on examining the transcriptional targets of hypoxia inducible factors (HIFs).HypothesisEpigenetic changes mediate the effect of hypoxia …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Immunotherapy for autoimmune disease using T cell receptor-modified T-regulatory cells
Autoimmune diseases affect approximately 5% of Australians. Well known examples include type I diabetes, multiple sclerosis and rheumatoid arthritis. These diseases have unpleasant, and sometimes tragic, consequences for the affected person and are a costly burden on our health system. As treatment is often limited to managing symptoms, new therapies for autoimmune diseases are much desired.Many autoimmune diseases are tightly associated with inheritance of a particular allele at the major histocompatibility complex (MHC, also called human leucocyte antigen or HLA). …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Investigating genetic variants involved in Wilson disease and copper metabolism using genome editing
Wilson disease (WD) is a genetic disorder of copper metabolism. It can present with hepatic and neurological symptoms, due to copper accumulation in the liver and brain (1). WD is caused by compound heterozygosity or homozygosity for mutations in the copper transporting P-type ATPase gene ATP7B. Over 700 ATP7B genetic variants have been associated with WD. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. Early diagnosis and treatment are important for successful management of the disease. …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Genomics and Personalised Health
Identification and functional characterisation of genetic modifiers of iron overload
Iron is an element essential for virtually all life forms; aberrant iron metabolism is linked to many diseases. These include cancers, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, iron overload and iron deficiency disorders, iron-loading anaemias, and the anaemia associated with chronic disease. Central to proper iron regulation is the appropriate expression and activity of the liver-expressed regulatory peptide, hepcidin, and the iron exporter, ferroportin (FPN). Modulating the expression and activity of hepcidin and FPN, and their interaction is …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Investigation of genetic factors that contribute to concussion and its outcomes
The health outcomes from traumatic brain injuries (TBIs) and concussion depend on the nature of the injury, but response also varies greatly between individuals, suggesting that genetic factors may play a role. In particular, due to effects of head trauma on balances of ions, neurotransmitters and energy use in the brain, there is suggestion that variation in the genes that encode proteins involved in these pathways, e.g. ion channels, may affect the risk of, as well as response to a …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Should Australia legislate to allow three parent babies?
In 2015, the United Kingdom legalised a form of in vitro fertilisation (IVF) therapy known as ‘three-parent IVF’ and, less colloquially, mitochondrial replacement therapy (MRT). This IVF procedure is aimed at enabling women who have mitochondrial diseases that would normally be passed down to their offspring to have a healthy child instead. The technique involves removing faulty mitochondria from the intended mother’s egg and replacing them with mitochondria from a generically unrelated woman (by transferring the intended mother's nucleus to …
- Study level
- PhD
- Faculty
- Faculty of Business and Law
- School
- School of Law
- Research centre(s)
-
Australian Centre for Health Law Research
Supporting Boundary Management in Young People’s AI Companion Interactions
We invite applications for a PhD position within an interdisciplinary research team examining how young people engage with AI companion chatbots (e.g., Character.AI, Replika) and how they manage risks and boundaries in these interactions.AI companions have grown in popularity since the COVID-19 pandemic and are increasingly used by young people seeking connection. This trend raises important concerns, including exposure to harassment, misinformation, and self-harm, as well as the potential impact on human relationships when reliance on AI companions becomes significant.This …
- Study level
- PhD
- Faculty
- Faculty of Science
- School
- School of Computer Science
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