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Australian Ganoderma species for the production of bioactive metabolites and new functional materials synthesis

Fungi are essential components of all ecosystems in roles including symbiotic partners, decomposers and nutrient cyclers and as a source of food for vertebrates and invertebrates. While vital to soil health and organic matter turnover, fungi have great potential in sustainable design and medicine.Ganoderma strains in particular produce bioactive compounds and display growth characteristics that favour their use in medical and applied biotechnology. Some species produce triterpenoids, such as ganoderic acids, and have been used in traditional Asian medicine for …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Understanding the external surface of fungal mycelia

The way in which fungal cultures grow in liquid cultures are can have a major impact on scale up and producing material. Here, we will examine the growth of three fast-growing filamentous fungi and try understand how various growth parameters affect the morphology that will range from loose mycelia to compact pellets.Fungal morphology is affected by inoculum (form, concentration and growth stage), media components (type and concentration of carbon, nitrogen and phosphate, trace minerals, pH, salt content), dissolved gases (dissolved …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Optimising outcomes for children and adolescents diagnosed with cancer

Each year in Australia, around 1200 children and adolescents are diagnosed with cancer and while most (84%) will achieve 5-year disease free survival, all will suffer significant distress from symptoms associated with cancer and treatment.High symptom burdens can lead to numerous negative outcomes that persist for many years beyond cancer treatment. These include disruptions normal development, schooling, relationships, careers, and living an independent life. This is concerning, because young people have a long time to live with these negative consequences, …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Nursing
Research centre(s)
Centre for Healthcare Transformation
Cancer and Palliative Care Outcomes Centre

Renewal and differentiation in human neural stem cells and their application to understanding neurological disorders

The effective regeneration of brain tissue requires an understanding of the factors mediating the damage as well as the integration of new/replacement cells to form new functional neural networks. The isolation and expansion of human stem cells and limited neural lineage differentiation have provided the foundation for strategies in the treatment of neurodegenerative disorders. We utilise iPSC-derived NPCs and patient-derived (Alzheimer’s disease; AD) iPSCs and neural lineage differentiation of hMSCs, iPSC NPCs and AD iPSCs in neuronal and glial culture …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Investigating DNA repair mechanisms in aging adult stem cells

When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2).However, we still lack a clear understanding on how the decrease in DNA repair …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Design, Simulation and Implementation of a Reliable PV Fault Detection Technique

Faults in any elements such as modules, lines, DC-DC converters and DC-AC inverters of photovoltaic (PV) systems can impact the reliability of the system and exacerbate the efficiency. Some other faults such as ground-fault might lead to significant issues such as the risk of fire. Therefore, it is crucial to investigate and detect the faults in the PV system and prescribe the appropriate actions.The supervisory team is looking for passionate students who are keen to conduct an overarching review and …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Engineering
School
School of Electrical Engineering and Robotics
Research centre(s)

Centre for Clean Energy Technologies and Practices

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