QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 45 matching student topics
Displaying 1–12 of 45 results
Mathematical modelling of cell-to-cell communication via extracellular vesicles (EVs)
Extracellular vesicles (EVs) are membrane bound packages of information constantly being released by all living cells, including bacteria. There are many types and sizes of EVs. Each EV type contains its own distinctive cargo consisting of characteristic DNA, RNA, and proteins. We are just beginning to understand the many roles of EVs to maintain the health of the cell producing the EVs, and to communicate with other cell types that take up the EVs produced by neighbouring cells. Since EVs …
- Study level
- Honours, Vacation research experience scheme
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
Extraction and formulation of astaxanthin produced in Phaffia rhodozyma fermentations
Traditionally derived from unsustainable petrochemicals, astaxanthin (AX) can also be sustainably produced by microbial fermentation. The yeast Phaffia rhodozyma naturally produces AX as its main fermentation product through sugar assimilation.In previous studies, we improved the bioprocess to produce (upstream) AX in P. rhodozyma. This project aims to investigate the extraction, recovery, and formulation (downstream) of the AX produced in our improved AX production process.AX is a carotenoid pigment and potent antioxidant naturally occurring in some ocean animals such as salmonids …
- Study level
- Master of Philosophy, Vacation research experience scheme
- Faculty
- Faculty of Science
- School
- School of Biology and Environmental Science
- Research centre(s)
- Centre for Agriculture and the Bioeconomy
A mathematical model of disrupting cell-to-cell communication by bacteria
The emergence of resistance of bacteria to antibiotics presents a global healthcare challenge that intensifies the search for strategies to increase the effcacy of therapy. Several mechanisms are involved in resistance of bacteria against antibiotics such as mutations in genes, horizontal gene transfer, and biofilm formation. Bacteria can communicate with each other through production and response to local concentration of small molecules called autoinducers.This mechanism is called quorum sensing (QS).It has been suggested that QS can influence the resistance of …
- Study level
- PhD, Master of Philosophy, Honours, Vacation research experience scheme
- Faculty
- Faculty of Science
- School
- School of Mathematical Sciences
- Research centre(s)
- Centre for Data Science
Understanding the role of TGF signalling intermediates in liver and iron-related disease
Transforming growth factor β (TGFβ) and its family members is involved in many phases of liver disease development and iron regulation. We have identified unexplored players in liver disease and iron-related disorders: TGF signalling intermediates. In this project, we build on our exciting findings to examine the molecular mechanisms involved in TGF signalling intermediates-mediated disease progression and their potential as targets for liver and iron-related disease.AimsThis project aims to:examine the expression of TGF signalling intermediates in the liverspecifically deplete TGF …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer
Prostate cancer is an androgen dependent cancer and treatments are aimed at preventing activation of the androgen receptor. Part of the development of resistance to therapies involves prostate cancers reprogramming their metabolism to overcome metabolic stress induced by these therapies and support growth and survival. This reprogramming involves increases in the rate of glycolysis and intermediate pathways branching from glycolysis. Previously in our laboratory, the natural compound, beta-carboline dimer, BD, was identified to have potent effects on cell viability, cell …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Potential for defective interfering particles (DIPS) to interrupt mammal-mosquito transmission of dengue virus
Dengue is a major mosquito-borne disease affecting 390 million people annually across 100 countries. Disease results from infection with dengue viruses, which are single positive-stranded RNA viruses in the family Flaviviridae. Defective interfering particles (DIPs) are virus-like particles with greatly reduced genomes that are byproducts of RNA virus replication and replicate only in the presence of standard virus (Vignuzzi and Lopez 2019, doi: 10.1038/s41564-019-0465-y). DIPs occur naturally during Dengue infection (Li et al. 2011, doi: 10.1371/journal.pone.0019447) and suppress DENV replication …
- Study level
- Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterisation of melanoma cell membranes to identify novel drug targets
Cell membrane structure and function are altered during tumour development, but to date comprehensive studies on the characterisation of cell membranes of a given cancer are scarce, or are only focused on a particular property (e.g. overall charge, global lipid composition, or specific lipid). In preliminary work we compared the lipidome (i.e. the lipid profile) of a panel of cells, and found the lipid composition of model melanoma cells to be distinct from that of other cancerous and non-cancerous cells. …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Application of fluorescence-activated cell sorting and confocal microscopy for the study of the microbial communities responsible for nutrient removal from domestic wastewater
The removal of nutrients like carbon, nitrogen and phosphorus from wastewater is critical to the prevention of eutrophication in receiving water systems and is carried out by complex microbial communities.Eutrophication can have devastating consequences on aquatic life and natural ecosystems, with toxic algal blooms also posing a risk to human health.Understanding the microbiology of phosphorus (P) removal from wastewater is considered essential to knowledge-based optimisation of enhanced biological P removal (EBPR) systems.Most of the species in these systems are novel …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Using machine learning to understand how the world’s microbiomes are changing due to climate
Shotgun metagenomic sequencing has become commonplace when studying microbial communities and their relationship with the health of our planet, and their direct effects on our own health. Currently, there are >180,000 shotgun metagenomes publicly available, but until recently trying to treat these data as a resource has been challenging due to its extreme size (>700 trillion base pairs).Recently we have developed a tool that can efficiently convert this base pair information into a straightforward assessment of which microorganisms are present …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Searching for Life on Mars on Earth
NASA's newest Mars rover, Perseverance, has just arrived on the red planet. Tasked with searching for ancient life in the geological record of a ~4 billion-year-old crater lake, the mission science team must use our only available analogue - the Earth - as their guide to exploration.
- Study level
- PhD
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
Probing the origins of life on Earth
The history of life on Earth is written in the fossil record. In this project, you will investigate stable isotope evidence for extremely early evolving organisms. Through careful petrography and with the use of isotope ratio mass-spectrometers, you will help unravel the history of microbial metabolisms that powered the ecosystems recorded by 3 billion-year-old microbial fossils.
- Study level
- Master of Philosophy, Honours, Vacation research experience scheme
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
A novel molecular targeted therapy for anaplastic prostate cancer
In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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