QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 8 matching student topics
Displaying 1–8 of 8 results
Targeting leptin's signalling axis to prevent treatment resistance in prostate cancer
Advanced prostate cancer (PCa) is a leading cause of cancer-associated death in Australian men. Anti-androgens, which exploit the tumour’s reliance on androgens for its growth & spread, offer temporary remission in advanced PCa patients, but due to treatment resistance, fail to be curative. A further complication of anti-androgens is that they trigger a deleterious suite of metabolic side-effects resembling obesity/Metabolic syndrome. These symptoms not only impact patient health but promote tumours to be more aggressive & resist treatment. Vital new …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Restoring adiponectin signalling to prevent prostate cancer progression
Advanced prostate cancer (PCa) is a leading cause of cancer-associated death in Australian men. Anti-androgens, which exploit the tumour’s reliance on androgens for its growth and spread, offer temporary remission in advanced PCa patients, but due to treatment resistance, fail to be curative. A further complication of anti-androgens is that they trigger a deleterious suite of metabolic side-effects resembling obesity/Metabolic syndrome. These symptoms not only impact patient health but promote the tumour to be more aggressive and resist treatment. Vital …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Involuntary Treatment for Mental Illness: Under what circumstances is it ethically justified?
Dr Sam Boyle is looking for candidates wanting to explore the ethical and legal issues associated with providing involuntary treatment for people with mental illnesses. Candidates may explore this issue in relation to ethics, human rights, or any other relevant angle, including an international comparative approach.
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Business and Law
- School
- School of Law
- Research centre(s)
-
Australian Centre for Health Law Research
Developing a precision oncology workflow for Osteosarcoma treatment
Osteosarcoma (OS) is the most common malignant bone tumour that primarily affects children and adolescents. With approximately 400 diagnosed cases/year in Australia, OS has the lowest survival rate of all solid cancers and is the leading cause of cancer-related death in Queensland adolescents. Unfortunately, 3 in 4 patients will not survive longer than five years following diagnosis with metastatic OS. Clinical “one size fits all” treatment strategies results in highly variable and unacceptably poor patient responses. Shockingly, both the OS …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Dietary counselling for nutrition-impacting symptoms during cancer treatment
Nutrition-impacting symptoms contribute to decreased quality of life and food intake, and subsequent malnutrition and decreased willingness to commence or complete cancer treatment, which all compromise survival. Evidence exists to support the role of dietary counselling for malnutrition during cancer treatment; however, less is known about the role of dietary counselling for nutrition-impacting symptoms that lead to the development of malnutrition.This systematic review project will synthesise available evidence on the effect of dietary counselling interventions on nutrition-impacting symptoms (e.g., fatigue, …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Nursing
- Research centre(s)
- Centre for Healthcare Transformation
Cancer and Palliative Care Outcomes Centre
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Activity and potential of cannabidiol and related compounds for the treatment of neuroinflammation
Epilepsy is neurological disorder estimated to affect over 50 million people worldwide. Only 20–30% of epilepsy cases have a suspected cause. The remaining cases of epilepsies arise in the absence of obvious neurological deficits, intellectual disability, or brain injuries. Neuroinflammation has shown to be linked to neurological diseases such as epilepsy. Neuroinflammation is a normal response that helps to maintain equilibrium. When the inflammation continues for an extended period of time or is overactive it can cause cellular abnormalities seen …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Determining the response to PARP inhibitor treatment of ovarian cancer in mouse xenograft model
Our cellular DNA is constantly under threat from both exogenous and endogenous factors. DNA repair pathways function to maintain genomic stability, preventing deleterious mutations that may ultimately lead to cancer initiation. When a tumour forms, it becomes genetically unstable, allowing environmental adaptation. This genetic instability can also result in gene mutations and protein expression alterations that can be targeted to induce cancer-specific cell death (phenomenon also known as synthetic lethality). For example, it has been shown that cells deficient in …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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