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Found 166 matching student topics

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Pluses and minuses of lipid mass spectrometry

Lipids are among the most structurally diverse of all the biomolecules and thus deciphering their many functions requires bio-analytical technologies capable of uniquely identifying and quantifying individual molecules in a milieu of many thousands of analogues. Mass spectrometry is the pre-eminent technique for contemporary lipid analysis but is challenged by the preference of certain lipids to ionise with a polarity that affords sensitive detection but does not permit detailed structure elucidation. This project will develop advanced instrumentation capable of on-demand …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Pattern formation and nonlinear dynamics

Pattern formation is a field of research within the nonlinear sciences where the traditional disciplines of mathematics, physics, chemistry and biology merge, interact and exchange ideas.There are opportunities to conduct research into various aspects of the pattern formation processes from a mathematical perspective. These include the study (existence, stability and interaction) of localised structures such as travelling waves, pulses, stripes and spots in low-dimensional paradigm models, and the effect of small defects or heterogeneities on the pattern formation process. …

Study level
Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Mathematical Sciences

Development of 3D tumour models for radiobiological research

Approximately 40 percent of cancer patients will receive radiation therapy as part of the management of their disease. Radiation can be used alone or in combination with other treatment modalities such as surgery, chemotherapy, and increasingly immunotherapy.Optimising the delivery of radiation, to take advantage of new treatment planning and delivery techniques, or to test new combinations of treatment modalities in a pre-clinical setting, has traditionally been performed using single layer 2D cell cultures and small animal models.Recently, it has become …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Time resolved EPID based thickness measurements for radiotherapy treatment verification

Verifying the delivery of radiation during radiotherapy treatments is increasingly important. The patient position and delivered radiation dose are equally important for a successful clinical outcome. Electronic Portal Imaging Devices (EPIDs) can be used to measure the radiation dose exiting the patient. We have developed a method for converting the measured signal in the EPID to tissue equivalent thickness, a surrogate for radiation dose. This project will investigate the real time measurement of the patient thickness during radiation delivery. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Use of depth sensing technology in radiotherapy and medical imaging

Consumer-grade depth sensing technology has in recent years become widely available. A number of vendors have developed similar technologies.Some examples of these technologies include:Microsoft Kinect™ (now discontinued)Intel’s RealSense™Asus Xtion depth sensorQualcomm Spectra ISP platform, now in its second generation.The systems make use of camera technology that measures the distance to a surface. Rapid image acquisition can then enable real time motion detection of location of the surface. The infra-red transmitter and sensor use a time-of-flight method to construct a depth …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Develop and implement a non-contact real-time respiratory monitoring technique, using low cost 3D camera technology, and explore its use in abdominal-thoracic cancer sites

Consumer-grade depth sensing technology has in recent years become widely available. A number of vendors have developed similar technologies, for example, Microsoft KinectTM (now discontinued), Intel’s RealSenseTM, the Asus Xtion depth sensor, and the Qualcomm Spectra ISP platform, now in its second generation.The systems make use of camera technology that measures the distance to a surface, rapid image acquisition can then enable real time motion detection of location of the surface. The infra-red transmitter and sensor use a time-of-flight method …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

The use of Monte-Carlo techniques in radiotherapy

Various research projects are available in the use of monte-carlo techniques in radiotherapy and medical imaging. These include modelling radiotherapy linear accelerators, patient dosimetric verification and in-vivo treatment verification using electronic portal imaging devices.

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Managing motion in radiotherapy treatments

The outcomes of radiotherapy treatments are influenced by patient motion such as breathing during the delivery of the treatment.A number of research projects are available to investigate and develop new techniques for measuring and managing motion during the radiotherapy treatment. These include imaging and surface measurement during treatment.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Modelling and simulation of industrial processes and products

Industrial processes and products can be described as 'multi-problems' in that they are often multi-scale, multi-phase and multi-component in nature. The analysis of such problems sits in the exciting nexus of applied mathematics, physical science and engineering science.

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Mathematical Sciences

Designing technology to promote physical activity in families with young children

The aim of this project is to engage with families with young children to design technologies that promote physical activity spread across the day. To promote healthy growth and development, children aged 1-5 years should be physically active for at least three hours each day. This may include running, jumping and playful activities. In this project we will explore how parents currently promote an active lifestyle, the technologies that they use, and the obstacles they may face to find the …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Electrical Engineering and Computer Science

Triplet energy transfer in organic solar cells

The physical process of singlet exciton fission permits conversion of one singlet exciton (S1) into two low energy triplet excitons (T1). This happens when two neighboring molecules form a triplet intermediate state that is of singlet character, which then breaks down at ultrafast time scales into two triplet states via S1 + S0 → T1 + T1.The potential to have multiple charge carriers per absorbed photon in singlet fission (SF) active organic materials has attracted much attention for the enhancement …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Electrical Engineering and Computer Science

Preclinical irradiation setup optimisation for immunotherapy-radiotherapy combination treatment in triple negative breast cancer

Although effective treatment options are available for the majority of breast cancer patients, major unmet needs remain for treatment of metastatic disease and for treatments to prevent metastases in patients with the highly aggressive 'triple negative' breast cancer (TNBC) subtype.It has recently become appreciated that immuno-suppression within the tumour microenvironment plays an important role in modulating tumour progression and metastasis. Capitalising on this new understanding, novel classes of immunotherapeutic drugs have been developed which show promise to dramatically improve treatment …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

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