QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 16 matching student topics
Displaying 13–16 of 16 results
Spatial profiling of the tumour microenvironment
Lung cancers are the leading cause of cancer related deaths in Australia, with a 5-year survival of 15%. With the emerging success of immune checkpoint blockage leading to durable responses and prolonged survival in 15-40% of cases, there is now a need for predictive biomarkers to guide selection for immunotherapies.The immune contexture of the tumour microenvironment (TME) is an important factor in dictating how well a tumour may respond to immune checkpoint therapies (1). Spatial and immunological composition with cellular …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Understanding the role of the hSSB1 protein in the response to UV induced DNA damage
Melanoma is the 4th most common cancer in Australia. The link between skin cancer and UV exposure is now well established. If a DNA damage induced by UV exposure is left unrepaired, the mutation generated in the genome can lead to cell death or cancer. It is thus highly important to understand of how a cell can repair DNA damage. The main pathway to repair UV DNA damaged is the nucleotide excision repair pathway (NER) (Kamileri I. et al, Trends …
- Study level
- Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
An airway chip for screening viral infection mediated immune responses
Respiratory infections such as influenza, SARS-COV-2, COVID-19, and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk. Recent works showed that immunomodulatory therapy, with or without antiviral agents, may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which can't capture …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
Why do epithelial cells have antigen processing machinery?
Epithelial Cells (ECs) constitute the border between the host immune system and an environment teeming with inhaled antigens. Work from us and others has highlighted that ECs have the ability to express the antigen processing and presentation machinery, Major Histocompatibility Complex class II (MHC II) that is important in initiating immune responses. MHC II expression and function on mucosal epithelial cells, is not well understood.Whilst MHC II is expressed by ECs, and is altered with inflammation, there is a paucity …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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