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Found 7 matching student topics

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Smart biomaterials for tissue regeneration

Ageing and diseases usually result in tissue damage and organ failure. To regenerate functional tissues and restore organ function, bioactive materials with smart surfaces are essential to facilitate cellular activities.This project is to develop biomaterials actively engage with biological system to regulate and direct cell behaviour and tissue regeneration.

Study level
PhD
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Biofabrication and tissue engineering

Biofabrication and tissue engineering seeks to create 3D scaffolds containing cells to heal defected tissue.People suffering from tissue loss often have to have autografts (where tissue is transferred from one part of their body to the other, leading to 2 sites of surgery and associated morbididy)We use scanning modelling and 3D printing to create 3D scaffolds that can perfectly fit the defect site and may contain cells or growth factors to stimulate new tissue formation - this circumvents the need …

Study level
Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate ‘mini-tumours-in-a-dish’ from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Humanized models for pre-clinical osteosarcoma research

Osteosarcoma (OS) is the most commonly occurring malignant bone tumour, predominantly affecting children and adolescents. Most OS patients are treated with a combination of surgery (tumour resection) and systemic chemotherapy with Doxorubicin.Unfortunately local recurrence and subsequent metastatic spread still frequently occurs, with an ultimate five-year survival rate of only around 25% once metastasis has occurred. There has been no progress in the enhancement of overall OS patient survival in the last four decades. One of the main reasons for this …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Optimising bone shape with memory networks

Bone is a dynamic tissue that optimises its shape to the mechanical loads that it carries. Bone mass is accrued where loads are high, and reduced where loads are low. This adaptation of bone tissue to mechanical loads is well known and observed in many instances. However, what serves as a reference mechanical state in this shape optimisation remains largely unknown.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mathematical Sciences
Research centre(s)

3D-printed cellular structures for bone biomimetic implants

Bone implants have been increasingly used to repair and replace the host bones. One promising approach is creating three-dimensional (3D) porous cellular structures that provide suitable microenvironments to achieve the required integration and support under loading conditions.Both porosity and pore size have a direct influence on their functionalities for biomedical applications. Besides the intrinsic material properties of the polymers, the internal architecture of a cellular structure has a significant effect on its mechanical and biological behaviour.Improved specific mechanical properties have …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Materials Science
Centre for Clean Energy Technologies and Practices

Finite Element Analysis of the bone-cartilage interface: Developing new understanding of the interface biomechanics in arthritic joints

There is still much to learn about the biomechanics of the arthritic knee joint. In particular, improving our understanding of the osteochondral interface may prove to be a critical step in better understanding aetiology and treatment of the diseased joint.We believe combining the complementary approaches of experimental cell-biology and computational modelling will lead to a breakthrough.

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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