Metallo-supramolecular systems for Chiral Recognition

Overview

This project focuses on the design and study of new supramolecular assemblies - complex molecular systems formed through non-covalent interactions- that can recognise and distinguish chiral molecules. The ability to differentiate between these chiral enantiomers is critically important in areas such as pharmaceuticals, where different isomers can have very different biological effects.

As part of this project, students will contribute to the development and investigation of novel supramolecular systems for chiral sensing. Using advanced analytical techniques, particularly ion mobility mass spectrometry, the project will explore how these systems interact with and selectively bind different chiral molecules.

Research engagement

This is a laboratory-based project in which students will spend approximately equal time on the synthesis of supramolecular systems and their characterisation using advanced analytical techniques such as ion mobility mass spectrometry. This balanced approach provides a strong background on which to build your research skills.

Research activities

Students will:

- Gain an understanding of metallo-supramolecular design

- Assist in the synthesis and/or preparation of supramolecular assemblies

- Use ion mobility mass spectrometry (and related techniques) to study host–guest interactions

- Analyse how effectively different systems can distinguish between chiral molecules

Through this work, students will help address current limitations in both the synthesis of supramolecular systems and the analytical methods used to study them.

Research skills

By completing this project, you will have:

- Developed practical skills in synthetic chemistry

- Gained experience with advanced characterisation techniques and data interpretation, and

- Built an understanding of molecular recognition and metallo-supramolecular design principles

Outcomes

This research contributes to the development of highly selective sensing systems with potential applications in pharmaceutical analysis, and advanced materials manufacturing. Improving the ability to distinguish between chiral molecules has wide-reaching implications for both industry and fundamental chemical science.

Skills and experience

This project is best suited to a second or third-year chemistry students with:

- An interest in organic, supramolecular, or analytical chemistry

- Strong laboratory skills and attention to detail

- Curiosity about molecular design and advanced characterisation techniques

Start date

2 November, 2026

End date

19 February, 2027

Location

M6 synthesis lab

Additional information

lab coat, saftey glasses

Keywords

• supramolecular chemistry
• synthesis
• mass spectrometry

Contact

Kathleen Mullen

07 31382393

kathleen.mullen@qut.edu.au