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The impact of neuroretinal disease on circadian behavior and sleep

Chronic sleep disruption impacts on quality of life and can lead to cardiovascular disease and cancer (Cable et al, Ann N Y Acad Sci 2021). Importantly in people with underlying chronic health conditions, circadian disruption can exacerbate symptoms, disease severity and cause disease progression.Light signalled by photoreceptors in the retina is the most important cue for setting sleep/wake cycles. The impairment of this light signalling in eye and neurodegenerative disease leads to circadian and sleep disruption (Feigl & Zele, Optom …

Study level
Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Vision and Eye Research

Chronic toxoplasma gondii infection and degenerative diseases of the brain and retina

This project will test the central hypothesis that chronic Toxoplasma gondii infection contributes to degenerative diseases of the brain and retina. T. gondii is a protozoan parasite that is estimated to infect ~30% of the world’s population. The parasite invades the brain and retina, where it converts into a slowly-replicating form within a cyst. These cysts can remain latent (chronic infection) for the life of the individual without reactivation or causing clinical symptoms. However, there is increasing evidence from human …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Light, circadian rhythms and Parkinson’s disease

Up to 98% of patients with Parkinson’s Disease (PD) have non-motor symptoms (Poewe et al. Nature Rev Dis 2017, 3: 17013) and of those, circadian and sleep disorders are the most common (for review, Gros & Videnovic. 2020, Clin Geriatr Med 36: 119). These symptoms become increasingly prevalent during the course of PD and are key determinants affecting quality of life, advancement of overall disability and placement in nursing homes (Shapira et al. Nat Rev Neurosci 2017,18:435). Circadian and sleep …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences

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