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Polymer particles as precision sensors for molecules

Polymer particles are a billion-dollar industry with a diverse range of applications from biomedical to industrial coatings.As a prime example, point-of-care testing devices rely on polymeric particles with various size and functionality to conveniently allow instantaneous, selective, and precise diagnostics.However, as new applications arise and current applications advance, these demand the preparation of increasingly complex material and particle systems.The Soft Matter Materials Team has developed a simple method to form uniform particles without any additives, initiators or stabilisers.The ambient temperature …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Testing of novel antibiotic-loaded nanoparticles for treatment of Chlamydia infection

C. trachomatis, sexually transmitted infections of both the female and male human reproductive tract, affects approximately 127 million people globally each year. The major concerning sequela of C. trachomatis infection is infertility in both men and women. This occurs by damaging the upper reproductive tracts, the ovaries and testes most importantly.The majority of research has been focussed on female disease, and male disease has been underestimated and understudied, particularly therapeutics for male infections. Antibiotic therapy is the only therapy currently …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Can we beat nature in designing catalysts? Towards synthetic protein-structures based on precision macromolecules

Are you up for a challenge?In this project, you'll explore if you can beat nature in making catalytic systems!Over billions of years, nature has perfected the design and synthesis of high molecular weight precision macromolecules, which are able to execute a specific function in a complex biological environment, such as proteins.The project will be embedded into a large research effort within the Soft Matter Materials Team aimed at using precision synthetic polymer chemistry to design macromolecules that can be folded …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Online aerosol chemical characterisation using Particle Into Liquid Sampler coupled to Electrospray Ionisation Orbitrap Mass Spectrometry

Atmospheric aerosols are important as they have impact on earth’s climate and human health.Organic components represent a significant fraction of atmospheric aerosols. They can be directly emitted in the atmosphere or formed in the atmosphere by oxidation of gaseous precursors.Real-time characterisation of organic aerosol is required to understand their sources, formation and ageing (change) in the atmosphere.There are several mass spectrometry techniques currently used for real-time characterisation of organic aerosols. However, the techniques use hard ionisation, resulting in molecular fragmentation, …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
School
School of Earth and Atmospheric Sciences
Research centre(s)

Chemical characterisation of biomass burning smoke particles using Electrospray-Orbitrap mass spectrometry

Australian bushfires and prescribed biomass burning (BB) have a significant impact on both human health as well as global and regional climate.While emissions from traditional sources, such as vehicles and power plants are expected to decline due to more stringent regulations, air pollution from BB smoke is expected to continue growing.The impact of BB smoke particulate matter on human health will depend on their chemical and physical properties. However, that information for smoke from Australian ecosystems is very limited.The aim …

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Earth and Atmospheric Sciences
Research centre(s)

Potential for defective interfering particles (DIPS) to interrupt mammal-mosquito transmission of dengue virus

Dengue is a major mosquito-borne disease affecting 390 million people annually across 100 countries. Disease results from infection with dengue viruses, which are single positive-stranded RNA viruses in the family Flaviviridae. Defective interfering particles (DIPs) are virus-like particles with greatly reduced genomes that are byproducts of RNA virus replication and replicate only in the presence of standard virus (Vignuzzi and Lopez 2019, doi: 10.1038/s41564-019-0465-y). DIPs occur naturally during Dengue infection (Li et al. 2011, doi: 10.1371/journal.pone.0019447) and suppress DENV replication …

Study level
Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Can virus-based defective interfering particles (DIPS) be used to treat dengue infection?

Infection by dengue virus causes incapacitating and potentially dangerous acute disease in humans. Dengue is a mosquito-borne infectious disease with about 100 million serious clinical infections annually. Considerable effort in drug development is underway, but no effective drug therapy is available. A major difficulty for drug development is the rapid evolution of RNA viruses, like dengue virus, which presents a major challenge for controlling virus transmission and infection using conventional pharmaceuticals and vaccines.This project is based on the observation that …

Study level
Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

A golden approach to nanomedicine. Gold-polymer hybrid nanoparticles

Gold, a precious metal, is also highly valued for the production of highly functional nanoparticles.Gold nanoparticles interact with light and microwaves to generate heat and light, which can be used in nanomedicine for therapy or imaging.This project will look at developing polymer-gold hybrid nanoparticles to improve disease delivery and therapy. This project involves:polymer synthesismaterials formulationcharacterisation. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

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