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Engineering the prostate tumour microenvironment in organ-on-a-chip systems

Prostate cancer remains one of the leading causes of global death. The tumour microenvironment (TME) including blood vessels, immune cells, fibroblasts, and the extracellular matrix (ECM) possesses disease-specific biophysical and biological factors that are difficult to recapitulate using conventional in vitro cell culture models.The absence of these factors, however, causes cells to display abnormal morphologies, polarisation, proliferation, and drug responses, thereby limiting the ability to translate research findings from traditional cell culture into clinical practice.Recent advances in organ-on-a-chip technology enable …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, , and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk [1]. Recent works showed that immunomodulatory therapy with or without antiviral agents may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which cannot …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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