QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.

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Found 5 matching student topics

Displaying 1–5 of 5 results

Characterisation of a novel protein co-amplified with the n-MYC oncogene

The MYCN oncogene is amplified in a number of tumour types, including Neuroblastoma (NB) and Neuroendocrine Prostate Cancer (NEPC), where it is associated with worse patient prognosis, as compared to non-amplified tumours. However, the high expression of MYCN (encoding the n-MYC protein) alone in non-amplified tumours is associated with better patient prognosis and less aggressive disease. This suggests that other genes co-expressed in MYCN amplified tumours may be responsible for mediating the aggressive traits of n-MYC. Our team has identified …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

A novel molecular targeted therapy for anaplastic prostate cancer

In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Functional characterisation of putative salicylic acid hydroxylases from banana (Musa spp.)

Bananas (Musa spp.) are one of the most important fruit crops worldwide and are consumed by millions of people as a staple food. However, bananas are under threat from a wide range of fungal, bacterial and viral diseases which significantly impact their production and quality. Salicylic acid plays a key role in plant-microbe interactions and acts as a vital component in systemic acquired resistance (SAR), enabling plants to mount a long-lasting defence response against a wide range of pathogens. In …

Study level
Honours
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Post-translational modification of proteins in cancer

The Protein Ablation Cancer Therapeutics (PACT) laboratory are interested in understanding how post-translational modifications contribute to the tumorigenic functions of proteins in cancer cells. We hypothesise that particular post-translational modifications are required for the cancer-associated function of a protein and that prevention of these would be a useful approach to treating cancer.The aim of this project is to select a candidate protein from our database of potential targets, confirm the protein is modified, identify the key modified lysine in the …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Illuminating the microbial world using genome-based fluorescence microscopy

Our understanding of microbial diversity on earth has been fundamentally changed by metagenomic characterisation of natural ecosystems. Traditional approaches for visualising microbial communities are time-consuming and provide limited information about the identity of specific microorganisms.The proposed research aims to combine single cell genomics and super resolution microscopy for novel, high-throughput, genome-based techniques to visualise microorganisms, plasmids and viruses, with strain level specificity.The application of these highly scalable approaches will provide comprehensive and unprecedented insight into the fine-scale dynamics and evolution …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

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