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Physics-informed modelling for microfluidics

The miniaturisation of chemical and biological processes for gas sensing, water purification, cell culture and separation, and micro-reactors is an important factor to reduce costs while increasing performance and efficiency. Miniaturisation requires microfluidic tools for the precise manipulation of complex fluids at the microscale. Microfluidics offers several advantages such as speed, precision and control of those physical processes.However, the lack of fundamental understanding of the microscopic flow mechanisms, in particular the behaviour of non-ideal fluid mixtures, is a critical aspect …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

GPU acceleration for the lattice Boltzmann method

The lattice Boltzmann method has recently gained popularity for modelling complex fluid​ dynamics including in microfluidics and bio-engineering. The method is computationally expensive, especially for 3D calculations.The aim of this project is to develop codes for the Lattice Boltzmann method that utilise the parallelism of graphics processing units (GPUs) to extend our capabilities for modelling flow phenomena.

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mathematical Sciences
Research centre(s)

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, , and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk [1]. Recent works showed that immunomodulatory therapy with or without antiviral agents may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which cannot …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

Excessive clotting (thrombosis) leads to the cardiovascular diseases such as heart attack and stroke, killing one Australian every 12 minutes. It has long been recognized that platelets play a central role in thrombosis and are unique in their ability to form stable adhesive interactions under conditions of rapid blood flow.We've recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights the remarkable platelet sensitivity to the shear stress gradients of blood flow disturbance. Importantly, we've found that current anti-thrombotic drugs, such …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

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