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Novel therapeutic strategies to treat advanced colorectal cancer

Colorectal cancer is a very common disease, with over 15,000 new cases diagnosed in Australia annually. Metastatic colorectal cancer describes advanced disease that has spread beyond the primary site. This is very aggressive and incurable in the vast majority of these patients. To improve outcomes for colorectal cancer, we are using cutting edge genomic and cell biology techniques to understand disease heterogeneity and optimise drug response. We are developing novel therapeutic interventions based on unique molecular signatures and are testing …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

A novel molecular targeted therapy for anaplastic prostate cancer

In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Understanding the external surface of fungal mycelia

The way in which fungal cultures grow in liquid cultures are can have a major impact on scale up and producing material. Here, we will examine the growth of three fast-growing filamentous fungi and try understand how various growth parameters affect the morphology that will range from loose mycelia to compact pellets.Fungal morphology is affected by inoculum (form, concentration and growth stage), media components (type and concentration of carbon, nitrogen and phosphate, trace minerals, pH, salt content), dissolved gases (dissolved …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Hydroponic mushroom production

Lions mane strains are capable of producing very small fruiting bodies (mushrooms) in static liquid culture. In this project we will try establish parameters and conditions that favour mushroom synthesis on a liquid surface. If we can understand how and why this species produces mushrooms on a liquid surface – we may be able to target genes that could improve yields and tendency to grow hydroponically.'Hericium erinaceum (Bull.: Fr.) Pers. is an edible fungus of great significance in medicine. It …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Big data analysis to aid ecological research

We're looking for multiple students to help us answer the question: 'How can we utilise information technology to aid ecological research?'Sensor networks bring ecologists and pattern recognition researchers together to make some applications possible. These applications include assessing risks from potential bird collisions, unobtrusive observations (where the presence of humans changes some animal behaviours) and studying spatial and temporal variation in biological processes.With a significant amount of data being collected from these applications, processing and mining this data is challenging. …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Science
School
School of Computer Science

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