QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 4 matching student topics
Displaying 1–4 of 4 results
Patient-derived oncology NAMs for preclinical breast cancer research and therapeutic evaluation
New approach methodologies (NAMs), including advanced 3D cultures and microphysiological systems (MPS), are creating new opportunities to develop more human-relevant approaches for preclinical cancer research. However, translating these technologies from established cell lines to patient-derived tumours remains challenging because of limited tissue availability, tumour heterogeneity and variability in model establishment and performance.Building on established QUT expertise in patient-derived bioengineered breast tumour models, this project will develop robust and reproducible patient-derived oncology NAMs for preclinical breast cancer research and therapeutic evaluation.Breast …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Automation-enabled microphysiological systems for multicellular oncology NAMs
New approach methodologies (NAMs), including microphysiological systems (MPS), are transforming preclinical cancer research by providing human-relevant alternatives to conventional preclinical models. However, increasing the biological complexity of these models also creates major challenges in reproducibility, scalability and experimental throughput.Oncology provides a compelling application for addressing these challenges. Tumours are complex tissues in which cancer cells interact dynamically with extracellular matrix, immune cells, vascular cells and other components of the tumour microenvironment. Reproducing these interactions in vitro requires technologies that can …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Developing in vitro 3D models to understand liver disease
Several studies have demonstrated the appropriateness of 3D organoid cultures over the conventional 2D cultures, the advantages of 3D models include replicating the complex attributes of the liver beyond liver-specific metabolism, such as increased cell density, organization, and cell–cell signalling, O2 zonation.In this project we will establish a novel in vitro 3D model to study hepatocyte biology in the context of liver disease. A more comprehensive approach to investigating the intercellular mechanisms of NAFLD will include co-culture of organoids with …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Understanding the role of TGF signalling intermediates in liver and iron-related disease
Transforming growth factor β (TGFβ) and its family members is involved in many phases of liver disease development and iron regulation. We have identified unexplored players in liver disease and iron-related disorders: TGF signalling intermediates. In this project, we build on our exciting findings to examine the molecular mechanisms involved in TGF signalling intermediates-mediated disease progression and their potential as targets for liver and iron-related disease.AimsThis project aims to:examine the expression of TGF signalling intermediates in the liverspecifically deplete TGF …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
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