QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 5 matching student topics
Displaying 1–5 of 5 results
Investigating the role of Neuropilin-1 in Triple-Negative Breast Cancer metastasis and chemoresistance
Triple-negative breast cancers (TNBC) are negative for Estrogen Receptor, Progesterone Receptor and HER2 expression, are clinically aggressive and are unresponsive to the available hormonal or targeted drugs used for other breast cancer subtypes, so that TNBC patients rely mainly on chemotherapy. TNBC accounts for 15-20% of all invasive breast cancer and patients have increased risk of recurrence, mortality and early metastatic progression. Thus, there is an urgent clinical need to develop improved treatment strategies for TNBC. Neuropilin-1 (NRP1) is a …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Testing a promising targeted therapeutic for triple-negative breast cancer
Triple-negative breast cancers (TNBC) are negative for Estrogen Receptor, Progesterone Receptor and HER2 expression, are clinically aggressive and cannot be treated with the available hormonal or targeted drugs used for other breast cancer subtypes. TNBC accounts for 15-20% of all invasive breast cancer and patients have increased risk of recurrence, mortality and metastases early during disease progression. There is an urgent clinical need to develop improved treatment strategies for these women since the median survival of patients with metastatic TNBC …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Eribulin effects on epithelial mesenchymal plasticity and therapy response
Epithelial mesenchymal plasticity (EMP) is a highly regulated and powerful cellular process that is fundamental in embryonic development (1), which is hijacked by cancer cells for metastatic progression and therapy resistance in epithelial cancers (2). Eribulin is a microtubule-inhibiting cancer drug discovered in sea sponges and approved for 3rd line therapy in metastatic breast cancer, which was shown to block EMP (3).We hypothesise that eribulin’s reversal of EMT will sensitise breast cancer cells to other therapies and ultimately improve patient …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Patient-derived oncology NAMs for preclinical breast cancer research and therapeutic evaluation
New approach methodologies (NAMs), including advanced 3D cultures and microphysiological systems (MPS), are creating new opportunities to develop more human-relevant approaches for preclinical cancer research. However, translating these technologies from established cell lines to patient-derived tumours remains challenging because of limited tissue availability, tumour heterogeneity and variability in model establishment and performance.Building on established QUT expertise in patient-derived bioengineered breast tumour models, this project will develop robust and reproducible patient-derived oncology NAMs for preclinical breast cancer research and therapeutic evaluation.Breast …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
Automation-enabled microphysiological systems for multicellular oncology NAMs
New approach methodologies (NAMs), including microphysiological systems (MPS), are transforming preclinical cancer research by providing human-relevant alternatives to conventional preclinical models. However, increasing the biological complexity of these models also creates major challenges in reproducibility, scalability and experimental throughput.Oncology provides a compelling application for addressing these challenges. Tumours are complex tissues in which cancer cells interact dynamically with extracellular matrix, immune cells, vascular cells and other components of the tumour microenvironment. Reproducing these interactions in vitro requires technologies that can …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
- Centre for Biomedical Technologies
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