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Powerful enzymes to break stuff and make stuff

We need new ways to re-use and recycle complex polymers like plastics and biomass. With biological approaches we could potentially break polymers down into their monomeric components and convert these into new and different materials.This project focuses on improving our understanding of laccases - a powerful class of enzymes that can both break down and rebuild lignin (and potentially some plastics).There is a big functional divergence between bacterial and fungal laccases. Fungal laccases have very high redox potentials and can …

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer

Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Hearing colour and seeing sound – switchable optoacoustic imaging agents

Optoacoustic imaging is a relatively new medical imaging technique. It utilises laser light to excite an imaging agent, which in turn converts this light energy into heat. This heat is dissipated as a sound wave, which can be detected with an ultrasound receiver. This technique aims to overcome the minimal penetration depth of fluorescence imaging, and the lack of molecular specificity of ultrasound.In this project we are aiming to develop and synthesize intelligent imaging agents for optoacoustics, which are able …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

A golden approach to nanomedicine: gold-polymer hybrid nanoparticles

Gold, a precious metal, is also highly valued for the production of highly functional nanoparticles.Gold nanoparticles interact with light and microwaves to generate heat and light, which can be used in nanomedicine for therapy or imaging.This project will look at developing polymer-gold hybrid nanoparticles to improve disease delivery and therapy. This project involves:polymer synthesismaterials formulationcharacterisation.

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

Exploring chemotherapy-induced molecular aging and its relationship to exercise

Ovarian cancer is the sixth most common cause of death from cancer in women, with a five-year survival rate of less than 45 per cent. However, there is emerging research that shows the benefits of exercise therapy during recovery following certain cancer treatments, and how exercise can improve and extend the lives of women with ovarian cancer.This project is a collaboration exploring these health and survival outcomes in ovarian and other gynaecological cancers, and in particular how new diagnostic testing …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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