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Identification of novel melanoma biomarkers using exosomes

Tumour cells excrete exosomes, membrane vesicles (30-150 nm diameter) that encapsulate and transport proteins, metabolites and genetic material. They mediate intercellular communication within the tumor microenvironment, metastasis formation via circulation, and development of drug resistance. Circulating tumor-derived exosomes can be isolated from blood patients as a non-invasive liquid biopsy.The chemical composition and overall properties of the exosomal membranes are expected to be similar to those of parent cell membranes and to modulate blood circulation time, and uptake and targeting of …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Pluses and minuses of lipid mass spectrometry

Lipids (fats) are an abundant and structurally diverse group of molecules with an equally diverse array of functions in cellular biology.This project will develop new analytical technologies - based on advances in mass spectrometry and ion chemistry - that enable the analyst to identify and quantify individual lipids present at low concentrations in biological mixtures comprising many thousands of distinct molecules.These new capabilities will drive the discovery of unknown lipids and map the complex biochemical pathways through which they are …

Study level
PhD, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Chemistry and Physics
Research centre(s)
Centre for Materials Science

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