QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 479 matching student topics
Displaying 433–444 of 479 results
Visualisation of CRISPR targets
CRISPR-Cas9 technology allows us to modify virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the 'guide RNAs' that will control where modifications occur.We have developed a software pipeline, named Crackling, to identify safe and effective guide RNAs across entire genomes. We're now seeking to develop a visualisation to communicate the results produced by …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Computer Science
- Research centre(s)
- Centre for Data Science
Assessing reef restoration using MARRS Reef Stars on the Great Barrier Reef
The Bait Reef rehabilitation project commenced in early 2021 (site surveys, risk assessments and approval processes) and installation on-site occurred in October 2021. Since installation there has been monitoring of the Reef Stars in June 2022, February 2023, and January 2024.Thermal bleaching impacts in early 2022 and rapid colonisation of the area by soft corals meant that by February 2022 more than 50% of the original coral fragments had died. Subsequently, in August 2023 all dead fragments (still attached to …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
- Research centre(s)
- Centre for Data Science
Identification and characterisation of IRX4 isoforms as novel targets in prostate cancer
Prostate cancer (PCa) is the second leading cause of cancer-related death in Australian men. There is no cure for advanced prostate cancer patients who develop resistance to currently available treatments. Alternative splicing (AS) is tightly regulated to maintain genomic stability in humans (Liyanage et al 2019). Aberrant RNA splicing of cancer-causing genes has been reported as a major cause of treatment escape in prostate cancer patients. Iroquois-class homeodomain protein 4 (IRX4) is a TALE homeobox transcription factor which has been …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Determining the theapeutic efficiency of epigenetic drugs in ovarian cancer
Because cancer and many diseases arise from a combination of genetic propensity and the response of cells to external factors mediated through changes to the expression of key genes, it is important to understand epigenetic regulation. The epigenome is crucial to the changes of gene expression and there is now strong evidence that epigenetic alterations are key drivers of cancer progression. However, very few drugs targeting epigenetic modifiers have been successful, in part due to the lack of effective means …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Engineering Chimeric Antigen Receptor (CAR) T cell for the treatment of cancer
Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They do so through the CAR, which recognises specific antigens expressed on cancer cells. CAR T cell therapy has emerged as an effective form of cancer immunotherapy in certain types of blood cancers and are now approved for use in patients. However, CAR T cell therapy can only benefit a very small proportion of cancer patients at present because it is very …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Comprehensive strain-level characterisation of microbial communities associated with inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors 1,2. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD 2-5, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression.Previous IBD studies have been largely limited to older sequencing methods with low phylogenetic and functional resolution. Furthermore, these studies have predominantly …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Human-in-the-loop techniques to debug machine learning models
Machine learning models are being deployed in critical domains such as healthcare, education and fintech. The current approach to deploying machine learning models is based on considering a data-centric approach where the models are evaluated using performance measures on a test set. However, the high performance of the model on test data is not indicative of its reliability,An important aspect of reliability is in the understanding of what exactly a machine learning model encodes, and to verify if it learns …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Science
- School
- School of Information Systems
Identification and functional characterisation of genetic modifiers of iron overload
Iron is an element essential for virtually all life forms; aberrant iron metabolism is linked to many diseases. These include cancers, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, iron overload and iron deficiency disorders, iron-loading anaemias, and the anaemia associated with chronic disease. Central to proper iron regulation is the appropriate expression and activity of the liver-expressed regulatory peptide, hepcidin, and the iron exporter, ferroportin (FPN). Modulating the expression and activity of hepcidin and FPN, and their interaction is …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Critical evaluation of Star Formation Rate estimators in galaxies
This project aims to assess the reliability, accuracy, and limitations of various Star Formation Rate (SFR) estimators used in extragalactic astronomy. By leveraging multi-wavelength data from the ZFOURGE survey, the project will explore how well SFR indicators derived from UV, optical (Hα), infrared (IR), and radio observations compare to SED-fitted SFRs from CIGALE. The project will focus on understanding discrepancies, particularly in dusty star-forming galaxies and AGN hosts, and provide recommendations for improving SFR estimates in future research.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Chemistry and Physics
X-ray backscatter diffraction and X-ray fluorescence for the rapid structural and chemical characterisation of rock samples
The advisory team devised a synchrotron-based microscopy method for coeval measurements of elemental concentrations and crystal-orientation data combining X-ray fluorescence microscopy (XFM) with X-ray backscatter diffraction mapping (XBDM).We seek students with a background in physics, crystallography, or mineralogy and coding skills to help with the improvement of the methods.XBDM/XFM has the potential to become a game changer in the microphysical and -chemical characterisation of crystalline solids, with future applications in the critical-minerals industry and material science.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Science
- School
- School of Earth and Atmospheric Sciences
The role of childhood social-emotional learning competencies in adolescent health, education, and justice outcomes
This project aims to determine the relationship of childhood social-emotional competencies (particularly those developed by school-based social-emotional learning programs) with adolescent health, education, and justice outcomes. The project uses data from the NSW Child Development Study, a longitudinal study following the development of 91,597 children in NSW from birth.
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Health
- School
- School of Psychology and Counselling
Making seen what we can’t feel – wearable suns sensors for UV protection
Radiation exposure can be damaging, but at the right dose it can also have health benefits. An example, while ultraviolet (UV) light can cause skin damage and melanoma, it is also necessary for Vitamin D production. The key is knowing what dose we are receiving and when we have had too much. In this collaborative project with the School of Design, we are developing new wearable sun sensors that are sensitive to UV radiation, but also fashionable and desirable to …
- Study level
- Honours
- Faculty
- Faculty of Science
- School
- School of Chemistry and Physics
- Research centre(s)
- Centre for Materials Science
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