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Professor Tim Dargaville
Faculty of Science,
School of Chemistry & Physics
Biography
Research theme:Health
Research discipline:
Chemistry
Research centre: Centre for Materials Science
Website: https://research.qut.edu.au/pnb/
Research area
The inspiration behind Prof Dargaville's research is the development of new polymers and fabricated devices to help solve a number of important biomedical challenges. He has published >110 papers including 4 book chapters, is an inventor on two granted patents and made important contributions to the field of materials science and polymer chemistry. His areas of expertise include surface modification of polymers (PhD studies), effects of high energy radiation on polymers (post-doctoral position), synthesis of poly(2-oxazoline)s, biomaterials as implant devices, drug and vaccine delivery devices (all part of current position at QUT).
Skills include polymer synthesis (free radical and cationic mechanisms), polymer characterisation (a full suite of spectroscopic and analytical techniques), cell toxicity assays (e.g. to measure cytocompatibility of polymers with cells), and in vivo and ex vivo integration (using animal and ex vivo skin models to test biomaterial performance, integration and immune response). He is a consultant to hospitals, government laboratories and large/small companies in the areas of materials testing and new formulations. Very recently he has contributed to an Australian Diabetics Research Foundation project aimed at delivering pancreatic islets to treat type I diabetes by developing a polymer scaffold capable of enhancing blood supply to the islets and improving their viability and is also part of a research effort to vaccinate koalas against chlamydia using novel polymer implant devices.
Areas of expertise
- Polymers
- Biomaterials
- Silicone polymers
- Effects of radiation on materials including medical devices
- Poly(2-oxazoline)s as Biomaterials
- Polyesters for vaccine delivery in animals
- Delivery of anaerobic bacteria to the gut
Personal details
Positions
- Professor
Faculty of Science,
School of Chemistry & Physics
Research field
Macromolecular and materials chemistry
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020
Qualifications
- PhD (University of Queensland)
Professional memberships and associations
Teaching
Teaching discipline:
Teaching areas:
- SEB124 Understanding Chemistry (unit coordinator)
- CVB203 Physical Chemistry
- SEB304 Capstone
- Subject Area Coordinator for Chemistry/First Year Coordinator ST01
Publications
- Arasu, Y., Bryan, E., Russell, F., Huettner, N., Carey, A., Boyd, B., Beagley, K. & Dargaville, T. (2024). Enhanced clearance of C. muridarum infection using azithromycin-loaded liposomes. International Journal of Pharmaceutics, 650, Article 123709. https://eprints.qut.edu.au/247112
- Diaz, R., De-Juan-Pardo, E., Dalton, P. & Dargaville, T. (2023). Semi-Woven Structures via Dual Nozzle Melt Electrowriting. Macromolecular Materials and Engineering, 308(4), Article 2200526. https://eprints.qut.edu.au/242590
- Samson, K., Hidalgo-Alvarez, V., Dargaville, T. & Melchels, F. (2023). Tough, Resorbable Polycaprolactone-Based Bimodal Networks for Vat Polymerization 3D Printing. Advanced Functional Materials, 33(25), Article 2213797. https://eprints.qut.edu.au/239943
- Sanchez Diaz, R., Park, J., Rodrigues, L., Dalton, P., De-Juan-Pardo, E. & Dargaville, T. (2022). Highly Elastic Scaffolds Produced by Melt Electrowriting of Poly(L-lactide-co-e-caprolactone). Advanced Materials Technologies, 7(4), Article 2100508. https://eprints.qut.edu.au/229582
- Huettner, N., Goldmann, A., Hoogenboom, R. & Dargaville, T. (2022). Macrocyclization efficiency for poly(2-oxazoline)s and poly(2-oxazine)s. Polymer Chemistry, 13(27), 3975–3980. https://eprints.qut.edu.au/240544
- Mridha, A., Dargaville, T., Dalton, P., Carroll, L., Morris, M., Vaithilingam, V. & Tuch, B. (2022). Prevascularized Retrievable Hybrid Implant to Enhance Function of Subcutaneous Encapsulated Islets. Tissue Engineering - Part A, 28(5-6), 212–224. https://eprints.qut.edu.au/241114
- Rodrigues, L., Micallef, A., Pfrunder, M., Truong, V., McMurtrie, J., Dargaville, T., Goldmann, A., Feist, F. & Barner-Kowollik, C. (2021). A Self-Catalyzed Visible Light Driven Thiol Ligation. Journal of the American Chemical Society, 143(19), 7292–7297. https://eprints.qut.edu.au/211328
- Cometta, S., Bock, N., Suresh, S., Dargaville, T. & Hutmacher, D. (2021). Antibacterial Albumin-Tannic Acid Coatings for Scaffold-Guided Breast Reconstruction. Frontiers in Bioengineering and Biotechnology, 9, Article 638577. https://eprints.qut.edu.au/210248
- Dargaville, T., Harkin, D., Park, J., Cavalcanti, A., Bolle, E., Savi, F., Farrugia, B., Monnery, B., Bernhard, Y., Van Guyse, J., Podevyn, A. & Hoogenboom, R. (2021). Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to in Vivo Compatibility in a Murine Subdermal Implant Model. Biomacromolecules, 22(4), 1590–1599. https://eprints.qut.edu.au/210247
- Sarwat, M., Surrao, D., Huettner, N., St John, J., Dargaville, T. & Forget, A. (2020). Going beyond RGD: Screening of a cell-adhesion peptide library in 3D cell culture. Biomedical Materials, 15(5), Article 055033. https://eprints.qut.edu.au/204555
QUT ePrints
For more publications by Tim, explore their research in QUT ePrints (our digital repository).
Filter publications:
A complete list of publications is available at: https://www.qut.edu.au/about/our-people/academic-profiles/t.dargaville
Selected research projects
- Title
- Soft Materials Containing Hierarchy via 3d Sacrificial Micro-moulding
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT150100408
- Start year
- 2016
- Keywords
- Title
- Convergence of Biomaterials and Immunology - A Technology Platform for Delayed Burst Release of Vaccines
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP120104611
- Start year
- 2012
- Keywords
- Vaccine Delivery; Delayed Burst Release; Electrospinning; Vaccine Implant; Immune Response
- Title
- Investigation of the Role of Transglutaminases in the Signalling of Insulin-like Growth Factor 1 and its Derivatives
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- LP110201004
- Start year
- 2011
- Keywords
- Growth Factors; Cell Signalling; Wound Healing; Cancer
- Title
- Composite Biomaterials for Modulation of Dermal Fibroblast Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0877988
- Start year
- 2008
- Keywords
- Biomaterial; Hydrogel; Silicone; Fibroblast; Stratum Corneum
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
Current supervisions
- Design and Synthesis of Melt Processible Biodegradable Polyesters
PhD, Principal Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher, Dr Silvia Cometta Conde - Influence of Drugs on the Morphology of Poly(2-oxazoline)s
PhD, Principal Supervisor
Other supervisors: Associate Professor Nathan Boase - Oxidative Switching in the Serine Protease Degradome
PhD, Associate Supervisor - Studies on the Crystallinity of Polycaprolactone - Standard Melting Enthalpy Revisited
PhD, Associate Supervisor
Other supervisors: Dr Bronwin Dargaville, Distinguished Professor Dietmar W Hutmacher, Associate Professor Nathalie Bock - The 3D printing dynamics of melt electrowriting: Development of in-process control
PhD, Associate Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher
Completed supervisions (Doctorate)
- A Biodegradable Implant for Delayed Vaccine Delivery (2024)
- A nanoparticle-based approach towards clearance of intracellular chlamydia (2024)
- Development of a Biodegradable Delivery Device to Administer Vaccines to Animals: A Livestock and Wildlife Model (2024)
- Investigations into the macrocyclization of poly(2-oxazoline)s and poly(2-oxazine)s (2024)
- Immobilization of antimicrobial agents via physical and chemical modifications on medical-grade polycaprolactone for the prevention of biomaterial-related infections (2023)
- Inhaled ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticle dry powder inhaler formulation for the management of lower respiratory tract infections (2023)
- A biomaterials approach towards the expansion of melt electrowriting (2022)
- Advanced photochemical reactions induced by visible light (2022)
- Fabrication, Properties and Applications of PEGDA Hydrogels in Biomedical Science (2021)
- Poly(2-oxazoline) Architectures for Drug Delivery Systems (2021)
Completed supervisions (Masters by Research)
- Click chemistry gelatin hydrogels for 3D cell culture (2023)
- A Computational Fluid Dynamics Study of Scaffolds Under Perfusion Flow (2022)
- Bacterial Biofilm Treatment and In Situ Antimicrobial Coatings for Orthopaedic Implant Retention Surgery (2021)
- Mechanical Characterization of Multiphasic PCL Microfiber Hydrogel Composites for Articular Cartilage (2021)
- Peptide Functionalised Hydrogels for Tissue Regeneration (2020)
- Combining Melt Electrowritten Scaffolds and Silk Fibroin Films for Ocular Surface Regeneration (2019)
- Developing Hydrogel Systems for Biofabrication (2019)
- Light-Activated Nitrile Imine Mediated Reaction Pathways for The Synthesis of Bioinks (2019)
- Novel Approaches for Patterning Hierarchical Hydrogels (2018)
- A Simple Method Towards 3D-Printing and Crosslinking Partially Hydrolysed Poly(2-Ethyl-2-Oxazoline) (2017)
The supervisions listed above are only a selection.