Dr Annalese Semmler
Faculty of Health,
School of Clinical Sciences,
Pharmacy
Biography
Dr Annalese Semmler is a Senior Lecturer in the School of Clinical Science, Faculty of Health. She undertook her PhD at the University of Queensland’s Institute of Molecular Biosciences (IMB) focusing on the molecular characterisation of virulence factors produced by the pathogen Pseudomonas aeruginosa. On the completion of her PhD in 1998, she completed several successive postdoctoral positions encompassing research areas that include bacterial pathogenesis, lung diseases (cancer and COPD) and cardiovascular disease. During this time Dr Semmler also completed a small amount of teaching. Dr Semmler began teaching in the School of Clinical Sciences, Pharmacy discipline in 2011 and has done guest presentations in a couple of units in the School of Biomedical Sciences. Her teaching areas have been numerous but currently encompass cardiovascular and renal disease, neurology, mental health, cancer, pharmacogenomics, cell signalling, respiratory disease, future therapeutics, research skills and organisational strategies. Apart from teaching, Dr Semmler also leads the Molecular Human Cardiac Pharmacology research group based within the Faculty of Health, QUT. This group’s research focuses on the molecular processes by which pharmacological therapies are effective in treating heart disease and the pharmacogenomics affecting medications used to manage cardiovascular disease. She also has a number of additional research interests related to drug function (cancer drugs, antidepressants, cardiovascular drugs), pharmacogenomics and its implementation into the health care sector, cellular signalling and trafficking and strategies affecting HDR learning and critical thinking.Personal details
Positions
- Senior Lecturer
Faculty of Health,
School of Clinical Sciences,
Pharmacy- Kelvin Grove Q Block Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects - Kelvin Grove Q Block Membership
Keywords
Heart failure, Cardiovascular disease, Cell signal transduction, Pharmacogenomics, Pharmacology, Cancer, Respiratory disease, Epigenetics, Molecular microbiology, Cell trafficking
Discipline
Pharmacology and Pharmaceutical Sciences, Other Biological Sciences, Biochemistry and Cell Biology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- PhD (University of Queensland)
Professional memberships and associations
Member of ASCEPT
Member of ASMR
Participant in CSIRO STEM Professionals in Schools Partnership program
Teaching
Unit coordination and teaching SC45/47:
SCB638 Pharmacogenomics and drug metabolism (2011)
CSB473 Pharmacotherapeutics 2 (2015-2019)
SCB848/CSB483 Pharmacotherapeutics 3 (2012-2020)
Unit coordination and teaching CS47
CSB451 Patient Centred Care: Cardiovascular and Renal (2017-2021)
CSB465 Patient Centred Care: Mental Health (2018-2019)
CSH478 Evidence based healthcare: Research informing practice 1 (2018)
CSH489 Evidence based healthcare: Research informing practice 2 (2018)
CSH477 Evidence based healthcare: Practice informing research 1 (2022 - ongoing)
CSH484 Applying Research in Practice 2 (2018 - ongoing)
Guest teaching:
CSB453 Pharmacology 3
CSB461 Pharmacogenomics and drug metabolism
CSB463 Pharmacotherapeutics 1
CSB444 Medicinal Chemistry (ongoing)
CSB446 Patient Centred Care: Gastrointestinal (ongoing)
CSB451 Patient Centred Care; Cardiovascular and Renal (ongoing)
CSB454 Patient Centred Care: Respiratory (ongoing)
CSB456 Patient Centred Care: Oncology and Immunology (ongoing)
CSB464 Patient Centred Care: Neurology (ongoing)
CSB465 Patient Centred Care: Mental Health (ongoing)
CSH474 Applying research in practice 1
Guest teaching other schools (Nursing and Biomedical Sciences)
Allied Health Prescriber course
NSN430 Clinical Therapeutics
NSN422 Pharmacology and Therapeutics in extended nursing practice
LQB485 Cell Biology
LQB584 Medical Cell biology
LQB600 Physiological basis of pharmacology
Selected publications
- West Z, Aitcheson S, Semmler A, Murray R, (2021) The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages, Traffic, 22 (11), pp. 368-376.
- Chiang J, Zahari I, Markoulli M, Krishnan A, Park S, Semmler A, Goldstein D, Edwards K, (2020) The impact of anticancer drugs on the ocular surface, Ocular Surface, 18 (3), pp. 403-417.
- Rohl J, West Z, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey D, Semmler A, Murray R, (2019) Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface, Traffic, 20 (9), pp. 661-673.
- Savarimuthu Francis S, Tan M, Fung P, Shaw J, Semmler A, Nataatmadja M, Bowman R, Fong K, Yang I, (2013) Peripheral compartment innate immune response to Haemophilus influenzae and Streptococcus pneumoniae in chronic obstructive pulmonary disease patients, Innate Immunity, 19 (4), pp. 428-437.
- Goh F, Duhig E, Clarke B, Dettrick A, Godbolt D, Tran K, Franz L, Barr J, Parsonson K, Martins M, Davidson M, Wright C, De Laat J, Shaw J, Martin J, Parris B, Shaw E, De Souza L, Tjahjadi J, Daniels M, Larsen J, Semmler A, Stockwell R, Sava-rimuthu S, Relan V, Sriram K, Campbell J, Kim S, Tan M, Morrison L, Chee K, Impey E, Vaughan A, Rahman S, Chang N, Windsor M, Naidoo R, Matar K, Tam R, Cole P, Yang I, Bowman R, Fong K, (2013) Heterogeneity in tumour content and necrosis in primary lung cancers: Implications for molecular analysis, Journal of Thoracic Oncology, 8 (11 S2).
- Molenaar P, Savarimuthu S, Sarsero D, Chen L, Semmler A, Carle A, Yang I, Bartel S, Vetter D, Beyerdorfer I, Krause E, Kaumann A, (2007) (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through Beta2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling, Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (1), pp. 11-28.
- Javorsky G, Burstow D, Lolekha P, Lucas M, Semmler A, Savarimuthu S, Fong K, Yang I, Atherton J, Galbraith A, Parsonage W, Molenaar P, Chen L, Meyers D, (2007) Arg389Gly-[beta]1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol, Pharmacogenetics and Genomics, 17 (11), pp. 941-949.
- Molenaar P, Chen L, Semmler A, Parsonage W, Kaumann A, (2007) Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism, Clinical and Experimental Pharmacology and Physiology, 34 (10), pp. 1020-1028.
- Kaumann A, Semmler A, Molenaar P, (2007) The effects of both noradrenaline and CGP12177, mediated through human Beta1-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells, Naunyn-Schmiedeberg's Archives of Pharmacology, 375 (2), pp. 123-131.
- Bowman R, Yang I, Semmler A, Fong K, (2006) Epigenetics of lung cancer, Respirology, 11 (4), pp. 355-365.
QUT ePrints
To find publications by Annalese, visit QUT ePrints, the University's research repository.
Supervision
Current supervisions
- Evaluating treatment response in depression
PhD, Associate Supervisor
Other supervisors: Dr Joanne Voisey - EXPLORATION OF AN INTEGRATED ON-SITE RESIDENTIAL CARE PHARMACISTS IN THE AUSTRALIAN RESIDENTIAL CARE INDUSTRY?
PhD, Associate Supervisor
Other supervisors: Adjunct Professor Greg Kyle, Dr Vincent Chan, Associate Professor Viet Ngu Hoang
Completed supervisions (Doctorate)
- Characterising the Intracellular Trafficking of Matrix Metalloproteinase 14 in Macrophages (2021)
- Human Heart B-Adrenoceptors, Arrhythmias and Control by Phosphodiesterases (2019)
- B-Adrenoceptor Determinants of Contractility in the Human Heart: The Role of Phosphodiesterase Enzymes (2015)
- MOLECULAR MECHANISMS UNDERLYING PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) (2014)
- Molecular and Structural Requirements of the Beta1L-Adrenoceptor (2012)