Filter by faculty:

Found 12 matching student topics

Displaying 1–12 of 12 results

Mosquito determinants of arbovirus transmission

Project code:QIMR08Area of Research:Infections and ImmunityProject aims and objectives:Dengue and dengue haemorrhagic fever (DHF) is a worsening global pandemic resulting from infection with the dengue viruses. The dengue viruses are transmitted through the bite of a mosquito, primarily the highly urbanised and anthropophilic species Aedes aegypti. We have current projects evaluating the vector competence of mosquitoes (capability of virus transmission), a novel anti-viral therapy using dengue Defective Interfering Particles, mosquito immunity and metabolism.Project methodology and resources:The student will participate in …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Microsatellite Instability as a determinant of chemotherapy sensitivity

Project code:QIMR07Area of Research:CancerProject aims and objectives:Colorectal cancer is a major cause of mortality in Australia. Late stage colorectal cancers usually treated with a battery of cytotoxic chemotherapeutics, including a drug called TAS-102. The efficacy of chemotherapy varies dramatically between patients due to reasons that are not entirely clear. We have evidence that microsatellite instability may influence how patients respond to TAS-102, and in this project, we will combine genome engineering using the CRISPR-Cas9 system with traditional cell culture techniques …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Spatial localization of immunoglobulin A in the gastrointestinal tract

Project code:QIMR05Area of Research:CancerProject aims and objectives:Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Dileneating immune response similarities between autoimmunity and chronic graft-versus-host disease

Project code:QIMR04Area of Research:CancerProject aims and objectives:Chronic graft-versus-host disease (GVHD) occurs in approximately 60-80% of long-term survivors of allogeneic stem cell transplantation (allo-SCT). This immunological complication is a major cause of morbidity and accounts for approximately one-quarter of the deaths in long-term transplant survivors. Clinical manifestations of chronic GVHD such as dry eyes, dry mouth and connective tissue disease closely resemble those of autoimmune disorders such as Sjogren's syndrome. Focal lymphocytic infiltrates of exocrine tissues (eg salivary glands), a characteristic …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Student in Transplantation Immunology

Project code:QIMR03Area of Research:CancerProject aims and objectives:Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Chimeric Antigen Receptor (CAR) T cells for the treatment of cancer

Project code:QIMR02Area of Research:CancerProject aims and objectives:Chimeric Antigen Receptor (CAR) T cells are genetically modified immune cells that can recognise and kill cancer cells. They are a type of cancer immunotherapy that can be very effective against certain types of blood cancers and are now approved for use in patients. However, CAR T cells can only benefit a very small proportion of cancer patients at present. The aim of this project is to develop new types of CAR T cells …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

The effect of genetic predisposition to traits on recruitment bias

Project code:QIMR01Area of Research:CancerProject aims and objectives:Population based research projects only recruit those willing to take part in a study, therefore potentially introducing a recruitment bias. As part of the PISA study (Prospective Imaging Study of Aging: Genes, Brain, and Behaviour) we are leveraging our extensive in-house cohorts drawn from genetic studies of approximately 16,000 individuals. All participants have been invited to complete an online survey on cognition and behaviour, lifestyle and family history. The fact that we already have …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Human neural stem cell models

Project code:BIOM11Area of research:Molecular medicineProject aims and objectives:This project uses multiple human stem cell models along with cell culture and molecular biology techniques such as Q-PCR, Western Blot analysis and microscopy to examine the role of proteoglycans in lineage commitment and dysregulation. If we can understand and control lineage fate i.e. the formation of new neurons and astrocytes, we can understand how damage occurs and examine ways to treat and manage repair. This may include screening drugs or molecules to …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer

Project code:BIOM08Area of research:CancerProject aims and objectives:Our research is focussed on understanding the mechanisms that lead to therapy failure in prostate cancer and how these can be targeted to prevent cancer deaths. One way prostate cancers become resistant is by reprogramming their metabolism to overcome metabolic stress induced by treatment. We aim to identify drugs that can target metabolic networks that are unique to cancer cells.Previous work in our lab has identified a compound, BD, isolated from a sea squirt …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM04)

Project code:BIOM04Area of research:CancerProject aims and objectives:Bladder cancer (BlCa) is the 9th most common cancer in Queensland, with an estimated 53% five-year survival rate in Australians. Treatment options for superficial, locally advanced and metastatic BlCa include platinum-based chemotherapy and intravesical immunotherapy in the form of a bacillus Calmette-Guérin (BCG) vaccine - a weakened, live bacterium that stimulates the immune response. As a result of developed resistance or progressive growth, BlCa tumour recurrence is a common clinical outcome. Thus, there is …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM03)

Project code:BIOM03Project aims and objectives:Liver disease is a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism is associated with many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease.These two inter-related research themes are the focus of research in the Hepatogenomics Research Group in the School of Biomedical Sciences and IHBI; we hope to advance our understanding of these disorders at a molecular level with the …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Identifying biomarkers in children for predicting burn wound healing, to optimise wound care (BIOM02)

Project code:BIOM02Project aim:To identify protein biomarkers which are associated with poor wound healing outcomes in patients (e.g. needing a skin graft, scarring, delayed healing).Project methodology and resources:Blister fluid samples collected from patients are processed and analysed using mass spectrometry-based proteomic approaches. Proteins within the sample are identified and their abundance level characterised. The presence and amount of proteins within the sample are related to patient clinical parameters, using bioinformatic techniques. Students will gain an understanding of all these processes and …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Page 1 of 1