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Found 7 matching student topics

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Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate ‘mini-tumours-in-a-dish’ from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Improving mechanical properties of hydrogels for tissue engineering

Hydrogels provide a hydrated, extracellular, matrix-like environment that allow for the culturing and study of cells. However, hydrogels are typically soft and fragile, which limits their potential for load-bearing applications such as cartilage tissue engineering.This project aims to improve the mechanical properties of hydrogels for tissue engineering using a range of experimental and theoretical approaches.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, COVID-19, and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk [1]. Recent works showed that immunomodulatory therapy with or without antiviral agents may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which cannot …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, COVID-19, and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk. Recent works showed that immunomodulatory therapy, with or without antiviral agents, may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which can't capture …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Multi-microbial 3D printing for screening microbiome functions

The ability to 3D print bacteria has relevance to a wide range of applications, ranging from developing novel anti-microbial modalities to probiotics for promoting human health.Traditional culture techniques used in microbiology such as agar plates and suspension cultures have limited spatio-temporal control over the bacteria microenvironment as well as their interaction partners - in particular, mammalian host cells. This project aims to bridge this technological gap by combining 3D printing and microfluidics technologies to spatially control the localisation of multiple …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Humanized models for pre-clinical osteosarcoma research

Osteosarcoma (OS) is the most commonly occurring malignant bone tumour, predominantly affecting children and adolescents. Most OS patients are treated with a combination of surgery (tumour resection) and systemic chemotherapy with Doxorubicin.Unfortunately local recurrence and subsequent metastatic spread still frequently occurs, with an ultimate five-year survival rate of only around 25% once metastasis has occurred. There has been no progress in the enhancement of overall OS patient survival in the last four decades. One of the main reasons for this …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Biofabrication and tissue engineering

Biofabrication and tissue engineering seeks to create 3D scaffolds containing cells to heal defected tissue.People suffering from tissue loss often have to have autografts (where tissue is transferred from one part of their body to the other, leading to 2 sites of surgery and associated morbididy)We use scanning modelling and 3D printing to create 3D scaffolds that can perfectly fit the defect site and may contain cells or growth factors to stimulate new tissue formation - this circumvents the need …

Study level
Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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