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Bio-nano technology for immune defence

A fully-functioning immune system is essential to maintain good health, though such a system deteriorates with advancing age, contributing to increased susceptibility to infection, autoimmunity, and cancer.Relatively little research has been conducted on the impact of ageing on the innate immune response, which plays a crucial role in protecting against infection and represents a first line of defence. Macrophages are central effector cells of the innate immune system and have many diverse functions. This means age-related impairments in macrophage function …

Study level
PhD, Master of Philosophy, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Renewal and differentiation in human neural stem cells and their application to understanding neurological disorders

The effective regeneration of brain tissue requires an understanding of the factors mediating the damage as well as the integration of new/replacement cells to form new functional neural networks. The isolation and expansion of human stem cells and limited neural lineage differentiation have provided the foundation for strategies in the treatment of neurodegenerative disorders. We utilise iPSC-derived NPCs and patient-derived (Alzheimer’s disease; AD) iPSCs and neural lineage differentiation of hMSCs, iPSC NPCs and AD iPSCs in neuronal and glial culture …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Investigating DNA repair mechanisms in aging adult stem cells

When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2). However, we still lack a clear understanding on how the decrease in DNA …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Spatial localization of immunoglobulin A in the gastrointestinal tract.

Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment approaches to improve transplant outcome for …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation.

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Spatial localization of immunoglobulin A in the gastrointestinal tract

Project code:QIMR05Area of Research:CancerProject aims and objectives:Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Dileneating immune response similarities between autoimmunity and chronic graft-versus-host disease

Project code:QIMR04Area of Research:CancerProject aims and objectives:Chronic graft-versus-host disease (GVHD) occurs in approximately 60-80% of long-term survivors of allogeneic stem cell transplantation (allo-SCT). This immunological complication is a major cause of morbidity and accounts for approximately one-quarter of the deaths in long-term transplant survivors. Clinical manifestations of chronic GVHD such as dry eyes, dry mouth and connective tissue disease closely resemble those of autoimmune disorders such as Sjogren's syndrome. Focal lymphocytic infiltrates of exocrine tissues (eg salivary glands), a characteristic …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Student in Transplantation Immunology

Project code:QIMR03Area of Research:CancerProject aims and objectives:Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Human neural stem cell models

Project code:BIOM11Area of research:Molecular medicineProject aims and objectives:This project uses multiple human stem cell models along with cell culture and molecular biology techniques such as Q-PCR, Western Blot analysis and microscopy to examine the role of proteoglycans in lineage commitment and dysregulation. If we can understand and control lineage fate i.e. the formation of new neurons and astrocytes, we can understand how damage occurs and examine ways to treat and manage repair. This may include screening drugs or molecules to …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

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