QUT offers a diverse range of student topics for Honours, Masters and PhD study. Search to find a topic that interests you or propose your own research topic to a prospective QUT supervisor. You may also ask a prospective supervisor to help you identify or refine a research topic.
Found 51 matching student topics
Displaying 37–48 of 51 results
An airway chip for screening viral infection mediated immune responses
Respiratory infections such as influenza, SARS-COV-2, COVID-19, and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk. Recent works showed that immunomodulatory therapy, with or without antiviral agents, may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which can't capture …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Engineering
- School
- School of Mechanical, Medical and Process Engineering
Legal Approaches to Conservation Conflicts and Land-Use Conflicts
Conservation and land-use conflicts arise when people have different needs and interests concerning a protected area or land space. The management of these types of conflicts often has to broach disciplinary divides to ensure that appropriate consideration is given to the many complex and diverse issues that surround them, such as social justice, food production, biodiversity, the history of a place, and the attitudes and values of local stakeholders. The Law School invites students to express an interest in research …
- Study level
- PhD, Master of Philosophy
- Faculty
- Faculty of Business and Law
- School
- School of Law
A preclinical evaluation pipeline for new antivirulence drugs targeting multidrug resistant bacterial pathogens
A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.’ - WHO, 2014 (1). Antimicrobial resistance (AMR) is a global public health priority. If no action is taken, AMR is predicted to kill more people than cancer and diabetes combined by 2050, with 10 million deaths estimated each year and a global cost of up to 100 trillion USD. New therapies to tackle multidrug …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Characterisation of emerging multidrug resistant E. coli pathogens
The last fifteen years have witnessed an unprecedented rise in the rates of antimicrobial resistance among Gram-negative bacteria, described by the World Health organisation as a global health crisis (1). Escherichia coli sequence type 131 (E. coli ST131) is a ‘high-risk’ group of Gram-negative pathogens that have emerged rapidly and spread worldwide in the period of the last 10 years (2). E. coli ST131 strains are typically resistant to multiple classes of antibiotics and cause bloodstream and urinary tract infections …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Identifying novel pheno-endotypes in children with chronic cough
Chronic wet cough is among the commonest symptoms of chronic lung disease. In Australia, the most common cause of childhood chronic wet cough is protracted bacterial bronchitis (PBB), a clinical entity we first described. It has now been shown to be a precursor to bronchiectasis, which causes substantial morbidity and mortality, especially from acute respiratory exacerbations. Lung inflammation in children with persistent chronic wet cough is an important driver of ongoing and progressive tissue damage, leading to bronchiectasis, highlighting the …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Public Health and Social Work
- Research centre(s)
- Centre for Healthcare Transformation
Australian Centre for Health Services Innovation
QIMR06 - Improving bone marrow/stem cell transplant outcomes through pre-transplant modulation of donor T cell function
LocationQIMR Berghofer, HerstonBackground & HypothesisDonor stem cell/bone marrow transplantation (allo-SCT/BMT) is an important curative therapy in the treatment of blood cancers, however its application is limited by serious complications such as graft-versus-host disease (GVHD) that have a significant impact on patient mortality and quality of life.Early inflammatory responses during preparative transplant conditioning initiate a cascade of adaptive immune responses that manifest as acute and/or chronic tissue damage in >50% of transplant recipients.GVHD treatment options are relatively limited and focused on …
- Study level
- Vacation research experience scheme
- School
- School of Biomedical Sciences
QIMR05 - Evaluate blood cell free DNA for detection of actionable mutations for advanced lung cancer
LocationQIMR Berghofer, HerstonWe work across multiple different cancer types using a wide range genomics data, including whole-genome, whole-exome, panel sequencing and transcriptome to understand cancer development and treatment of cancer patients.BackgroundLung cancers remain the leading cause of mortality from cancer representing 18% of all cancer’s death, with a 5-year survival of only 10 to 20%. Most lung cancer patients are diagnosed at advanced stages of disease. For the majority of these patients the main method to acquire tumour material for …
- Study level
- Vacation research experience scheme
- School
- School of Biomedical Sciences
QIMR04 - Immunohistological localisation of pruritogenic mediators in scabies itch
With an annual prevalence of 100-300 million, scabies is one of the commonest skin diseases worldwide. Its incidence rate is higher than melanoma and keratinocyte carcinoma. This neglected tropical disease (NTD) is caused by the parasitic mite S. scabiei and is highly contagious. Therefore, it is a major global public health burden in crowded, resource-poor communities.In the Australian context, scabies is endemic in Indigenous Australian communities. Up to 80% of school-aged children in these communities have had scabies at least …
- Study level
- Vacation research experience scheme
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Traces of zinc and ciprofloxacin loaded polymer nanoparticulate inhaled formulations against lung infections associated with COPD and CF (CLIN08)
Lower respiratory tract infections (LRTIs) are one of the fatal diseases of the lungs that have severe impacts on public health, especially for Indigenous people. The currently available antibiotics administered orally for the treatment of LRTIs need high doses with frequent administration and cause dose-related adverse effects. To overcome this problem, we will investigate the development of ciprofloxacin (CIP) loaded poly(2-ethyl-2-oxazoline) (PEtOx) nanoparticles (NPs) with traces of zinc for potential pulmonary delivery from dry powder inhaler (DPI) formulations. As zinc …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Clinical Sciences
- Research centre(s)
-
Centre for Immunology and Infection Control
Biological and clinical impact of the association of germline variations in KLK3 (PSA) gene in prostate cancer
Prostate cancer is the most frequently occurring cancer (after skin cancers) in Australian males, and the second most common cause of cancer death. While the 5-year survival rate for localised disease approaches 100%, extra-prostatic invasion results in a poorer prognosis. Kallikreins are serine proteases, which are part of an enzymatic cascade pathway activated in prostate cancer (Lawrence et al 2010). The most well-known member is prostate specific antigen (PSA) or the KLK3 protein, encoded by the Kallikrein 3 (KLK3) gene, …
- Study level
- PhD, Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
Strain-level characterisation and visualisation of microbial communities associated with inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low resolution. Furthermore, these studies have predominantly focused on bacterial populations, …
- Study level
- PhD
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
Comprehensive strain-level characterisation of microbial communities associated with inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors 1,2. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD 2-5, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression.Previous IBD studies have been largely limited to older sequencing methods with low phylogenetic and functional resolution. Furthermore, these studies have predominantly …
- Study level
- Master of Philosophy, Honours
- Faculty
- Faculty of Health
- School
- School of Biomedical Sciences
- Research centre(s)
-
Centre for Microbiome Research
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