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PneuMatters: Preventing early-onset pneumonia in high-risk children through maternal immunisation - a study in Aboriginal, Torres Strait Islander, Māori, or Pacific Islander infants

The PneuMatters study is evaluating the efficacy of a pneumococcal vaccine in preventing pneumonia in the first 12 months of life in high-risk infants whose mothers received the vaccine while pregnant. The study is being conducted in Darwin, South-East Queensland and Malaysia. Participants are recruited in antenatal clinics and are followed until the baby turns 12 months of age.Australian participants must be pregnant with infants who will be identified as either Aboriginal, Torres Strait Islander, Māori, or Pacific Islander. This …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Public Health and Social Work

Why do epithelial cells have antigen processing machinery?

Epithelial Cells (ECs) constitute the border between the host immune system and an environment teeming with inhaled antigens. Work from us and others has highlighted that ECs have the ability to express the antigen processing and presentation machinery, Major Histocompatibility Complex class II (MHC II) that is important in initiating immune responses. MHC II expression and function on mucosal epithelial cells, is not well understood.Whilst MHC II is expressed by ECs, and is altered with inflammation, there is a paucity …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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